Unravelling the binding and activation mechanism of a complex G protein-coupled receptor

揭示复杂 G 蛋白偶联受体的结合和激活机制

• 批准号: nhmrc : GNT1100676
• 负责人: A/Pr Paul Gooley
• 金额: $ 104.16万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/unravelling-binding-activation-coupled-receptor/1346132
• 关键词: Unravelling; binding; activation; mechanism; complex

The peptide hormone relaxin is currently in a Phase III trial for the treatment of heart failure. However the peptide is not a good drug as it can't be taken orally and is very expensive to produce. We will study the interaction of relaxin with its cell surface receptor and the mechanisms by which the receptor functions. The knowledge gained will aid in the design of smaller, more potent and orally active forms of relaxin for the treatment of heart failure

肽激素松弛素目前正处于治疗心力衰竭的三期试验中。然而，这种肽并不是一种好的药物，因为它不能口服，而且生产成本很高。我们将研究松弛素与其细胞表面受体的相互作用以及受体的作用机制。所获得的知识将有助于设计更小，更有效和口服有效形式的松弛素治疗心力衰竭