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Defining the Molecular Mechanisms of Lyssavirus Replication and Immune Evasion: the P protein Axis

Defining the Molecular Mechanisms of Lyssavirus Replication and Immune Evasion: the P protein Axis
定义狂犬病病毒复制和免疫逃避的分子机制:P 蛋白轴
批准号:
nhmrc : GNT1125704
负责人:
A/Pr Paul Gooley
金额:
$90.1万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-01 至 --

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中文摘要
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英文摘要
Lyssaviruses such as rabies virus (RABV) and Australian bat lyssavirus cause rabies disease, which has the highest case-fatality rate of known infectious diseases, causing >60,000 human deaths/year. Critical to this is a protein produced by the virus that is important for both viral growth and evasion of the host's immune defences. This project aims to understand the molecular mechanisms underlying these processes, which may lead to new approaches to combat currently incurable viral diseases.
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Molecular determinants of drug binding and selectivity at muscarinic acetylcholine receptors
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  • 项目类别:
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  • 负责人:
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  • 项目类别:
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