The structural basis for biased agonism at the glucagon-like peptide-1 receptor

胰高血糖素样肽-1 受体偏向激动的结构基础

• 批准号: nhmrc : 1126857
• 负责人: Prof Laurence Miller
• 金额: $ 59.62万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-basis-biased-1-receptor/947872
• 关键词: structural; basis; biased; agonism; glucagon

The glucagon-like peptide-1 receptor plays an essential role in nutrient-regulated insulin release, and is a major target for therapeutic treatment of type 2 diabetes. The binding of different drugs to this receptor can promote distinct signalling profiles inside the cell that can lead to different physiological outcomes. Understanding the mechanistic basis for this will provide a framework to enable rational design of novel, better and safer therapeutics for the treatment of diabetes.

胰升糖素样肽-1受体在营养调节的胰岛素释放中起重要作用，是2型糖尿病治疗的主要靶点。不同药物与这种受体的结合可以促进细胞内不同的信号特征，从而导致不同的生理结果。了解这一机制的基础将提供一个框架，使合理设计新的，更好的和更安全的治疗糖尿病的疗法。