Toll-like receptor 2 signalling as a potential therapeutic target in gastric cancer

Toll 样受体 2 信号传导作为胃癌的潜在治疗靶点

• 批准号: nhmrc : GNT1088634
• 负责人: Dr Alison West
• 金额: $ 30.94万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/toll-like-receptor-gastric-cancer/1345741
• 关键词: Toll; like; receptor; signalling; potential

Stomach cancer is the fourth most deadly cancer in the world. Stomach cancer is closely linked with inflammation, and we have shown that a key inflammatory molecule, called toll-like receptor 2 (TLR2), can drive the development of stomach cancer. However, this occurs in a non-inflammatory manner. My research aims to understand how TLR2 is involved in the progression of stomach cancer, with the ultimate goal to find an early biomarker of disease, and to develop better therapies.

胃癌是世界上第四大致命癌症。胃癌与炎症密切相关，我们已经证明了一种称为Toll样受体2（TLR2）的关键炎症分子可以驱动胃癌的发展。然而，这是以非炎症的方式发生的。我的研究旨在了解TLR2如何参与胃癌的进展，最终目标是找到疾病的早期生物标志物，并开发更好的治疗方法。