Catalytic asymmetric reactions of sulfenes

亚磺基的催化不对称反应

• 批准号: 341537-2007
• 负责人: Manthorpe, Jeffrey
• 金额: $ 2.19万
• 依托单位: Carleton University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=429701
• 关键词: Catalytic; asymmetric; reactions; sulfenes

Sulfur-containing functional groups- sulfides, sulfoxides, sulfenes, sulfonamides, sulfonates, etc.- are present in a vast array of biologically and pharmacologically important molecules, including biotin, lipoic acid, methionine, cysteine, taurine, anti-biotic anti-tumor, anti-ulcer, anti-inflammatory, anti-diabetic, anti-asthma, anti-anemia, anti-viral, anti-psychotic, cardiotonic, anti-allergic and anti-migraine agents, as well as treatments for enlargement of the prostate gland and male erectile dysfunction. Included in this list are 14 of the 20 top grossing pharmaceuticals, with total sales of over $40 billion US in 2005 (US sales figures).

硫化物、亚硫醚、亚硫醚、磺胺、磺酸盐等含硫官能团存在于各种生物和药理上重要的分子中，包括生物素、硫辛酸、蛋氨酸、半胱氨酸、牛磺酸、抗生物制剂、抗肿瘤、抗溃疡、抗炎、抗糖尿病、抗哮喘、抗贫血、抗病毒、抗精神病、强心、抗过敏和抗偏头痛药物，以及治疗前列腺肥大和男性勃起功能障碍的药物。这份榜单包括20种最赚钱的药品中的14种，2005年美国的总销售额超过400亿美元(美国销售数据)。