Catalytic asymmetric reactions of sulfenes

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Sulfur-containing functional groups- sulfides, sulfoxides, sulfenes, sulfonamides, sulfonates, etc.- are present in a vast array of biologically and pharmacologically important molecules, including biotin, lipoic acid, methionine, cysteine, taurine, anti-biotic anti-tumor, anti-ulcer, anti-inflammatory, anti-diabetic, anti-asthma, anti-anemia, anti-viral, anti-psychotic, cardiotonic, anti-allergic and anti-migraine agents, as well as treatments for enlargement of the prostate gland and male erectile dysfunction. Included in this list are 14 of the 20 top grossing pharmaceuticals, with total sales of over $40 billion US in 2005 (US sales figures).