BioCage: a novel approach for biological containment of farmed fish

BioCage：一种养殖鱼类生物遏制的新方法

• 批准号: 350709-2007
• 负责人: Vandenberg, Grant
• 金额: $ 11.95万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Strategic Projects - Group
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=431305
• 关键词: BioCage; novel; approach; biological; containment

The proposed research project looks to find an innovative solution to the problem of the escape of farm-raised to fish. Over the past decade, fish escape from net pens has become highly politicized due to the concern that the escaped domestic fish may cause negative ecological impacts on wild fish stocks by out-competing for food and has a source of genetic pollution as a result of interbreeding with natural populations. The project will develop a line of transgenic fish expressing a specific factor that causes an increased requirement for a specific nutrient. Under artificial feeding regimes, the requirement for this nutrient will be covered. In the event offish escape, the escaped fish would be unable to survive due to the fact that the specific nutrient under question would not be found at high enough levels in the fish's natural prey. As a result of nutrient deficiency, escaped fish would lose condition, become anorexic, fail to reproduce and eventually die. The specific objectives of the project are 1) evaluate specific genetic constructs permitting an increase in specific nutrient requirement; 2) verify the ability of a model fish species to appropriately express selected gene construct; 3) validate the ability of nutritional manipulations to overcome higher levels of specific nutrient requirements. This project will open the door to the development of an innovative biocontainment strategy for farmed fish species and thus reduce the ecological impact of aquaculture production on wild fish stocks.

拟议中的研究项目旨在找到一个创新的解决方案，以解决养殖鱼类逃逸的问题。在过去十年中，鱼从网围栏中逃逸已变得高度政治化，因为人们担心逃逸的家鱼可能通过竞争食物对野生鱼类种群造成负面生态影响，并由于与自然种群杂交而造成遗传污染。该项目将开发一系列转基因鱼，表达一种特定因子，导致对特定营养素的需求增加。在人工喂养制度下，将涵盖对这种营养素的需求。如果鱼逃跑，逃跑的鱼将无法生存，因为事实上，所讨论的特定营养素不会在鱼的天然猎物中发现足够高的水平。由于缺乏营养，逃逸的鱼会失去状态，变得虚弱，无法繁殖，最终死亡。该项目的具体目标是：1）评估允许增加特定营养需求的特定遗传结构; 2）验证模式鱼种适当表达选定基因结构的能力; 3）验证营养操纵克服更高水平特定营养需求的能力。该项目将为制定养殖鱼类创新生物遏制战略打开大门，从而减少水产养殖生产对野生鱼类种群的生态影响。