Understanding the complexity of antigen presentation

了解抗原呈递的复杂性

• 批准号: nhmrc : 1137739
• 负责人: Prof Anthony Purcell
• 金额: $ 52.37万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-complexity-antigen-presentation/1318606
• 关键词: Understanding; complexity; antigen; presentation

I have developed and established the use of mass spectrometry to identify and quantitate ligands of antigen presenting molecules to understand the breadth of immune responses in a variety of human disease states including autoimmunity, cancer, infection and allergy. By embedding the technology in disease focussed research programs I will define the molecular bases of these diseases and the important immunological targets that will provide new avenues for therapeutic development and vaccines.

我已经开发并建立了使用质谱法来鉴定和定量抗原呈递分子的配体，以了解各种人类疾病状态下免疫反应的广度，包括自身免疫，癌症，感染和过敏。通过将这项技术应用于以疾病为重点的研究项目，我将确定这些疾病的分子基础和重要的免疫学靶点，这将为治疗开发和疫苗提供新的途径。