Biosynthesis, folding and modification of conotoxins

芋螺毒素的生物合成、折叠和修饰

• 批准号: DP110101331
• 负责人: Prof Anthony Purcell
• 金额: $ 23.22万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-05-05 至 2014-04-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP110101331
• 关键词: Biosynthesis; folding; modification; conotoxins

Disulfide-rich peptides represent a diverse family of bioactive molecules which have been developed as drugs for the treatment of severe pain. This project seeks to understand their biosynthesis and how their functional diversity is generated. Such information will assist the translation of more of these novel peptides into new drugs.

富含二硫化物的肽代表了一种不同的生物活性分子家族，已被开发为治疗严重疼痛的药物。该项目旨在了解它们的生物合成以及它们的功能多样性是如何产生的。这些信息将有助于将更多这些新型多肽转化为新药。