Mass spectrometry facility for the quantitation and analysis of post-translationally modified peptides

用于定量和分析翻译后修饰肽的质谱设备

• 批准号: LE0882913
• 负责人: Prof Anthony Purcell
• 金额: $ 20万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Infrastructure, Equipment and Facilities
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-05-31 至 2008-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LE0882913
• 关键词: Mass; spectrometry; facility; quantitation; analysis

This proposal will address a gap in our mass spectrometry capabilities and aid in our understanding of the cellular immune response and investigate the chemical diversity of the targets of immunity. This proposal has broad implications in the basic immunology of antigen presentation, in biomarker discovery as well as in the design of new vaccines in infectious disease and cancer and the development of therapies for autoimmune diseases. In addition to these key scientific outcomes this project will also facilitate the training of several new personnel in a skill area for which there is a critical shortage (mass spectrometry) and promote cross-disciplinary skills (immunology, biochemistry, proteomics).

这一建议将解决我们在质谱分析能力方面的空白，并有助于我们了解细胞免疫反应，并研究免疫靶点的化学多样性。这一建议在抗原呈递的基本免疫学、生物标志物的发现、传染病和癌症新疫苗的设计以及自身免疫性疾病治疗方法的发展方面具有广泛的意义。除了这些重要的科学成果外，该项目还将促进在一个严重短缺的技能领域（质谱）培训几名新人员，并促进跨学科技能（免疫学、生物化学、蛋白质组学）。