Antigen presentation during HLA B27 associated auotimmune disease

HLA B27 相关自身免疫性疾病期间的抗原呈递

• 批准号: nhmrc : 1022509
• 负责人: Prof Anthony Purcell
• 金额: $ 47.7万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/antigen-presentation-hla-auotimmune-disease/110195
• 关键词: Antigen; presentation; during; HLA; B27

Ankylosing spondylitis is a debilitating arthritic disease, susceptibility to which is conferred by genes of the immune system, particularly HLA-B27, and following gastrointestinal infection. Using mass spectrometry we will identify bacterial peptides bound to HLA-B27 on infected cells that may trigger an autoimmune response. Defining the self peptides that remain the targets of autoimmunity will unravel the molecular and cellular mechanisms if disease and identify peptides for immunotherapy.

强直性脊柱炎是一种使人衰弱的关节炎疾病，其易感性是由免疫系统基因（特别是HLA-B27）和胃肠道感染引起的。使用质谱分析，我们将确定与感染细胞上的HLA-B27结合的细菌肽，这些肽可能引发自身免疫反应。确定自身肽仍然是自身免疫的目标，将揭示疾病的分子和细胞机制，并确定用于免疫治疗的肽。