Antigen presentation during HLA B27 associated auotimmune disease
Antigen presentation during HLA B27 associated auotimmune disease
批准号:
nhmrc : 1022509
负责人:
Prof Anthony Purcell
金额:
$47.7万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2014-12-31
中文摘要
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英文摘要
Ankylosing spondylitis is a debilitating arthritic disease, susceptibility to which is conferred by genes of the immune system, particularly HLA-B27, and following gastrointestinal infection. Using mass spectrometry we will identify bacterial peptides bound to HLA-B27 on infected cells that may trigger an autoimmune response. Defining the self peptides that remain the targets of autoimmunity will unravel the molecular and cellular mechanisms if disease and identify peptides for immunotherapy.
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Understanding the complexity of antigen presentation
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批准号:nhmrc : 1137739
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项目类别:Research Fellowships
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资助金额:$52.37万
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财政年份:2018
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负责人:Prof Anthony Purcell
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依托单位:
Understanding the complexity of antigen presentation
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批准号:nhmrc : GNT1137739
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项目类别:Research Fellowships
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资助金额:$77.45万
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财政年份:2018
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负责人:Prof Anthony Purcell
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依托单位:
Next Generation Mass Spectrometry for Analysis of Biomolecules
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批准号:LE160100193
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$39.34万
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财政年份:2016
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负责人:Prof Anthony Purcell
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依托单位:
A study into post-translational modifications on adaptive immunity
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批准号:DP150104503
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项目类别:Discovery Projects
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资助金额:$29.13万
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财政年份:2015
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负责人:Prof Anthony Purcell
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依托单位:
Understanding determinant selection in autoimmune diseases
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批准号:nhmrc : 1044215
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项目类别:Research Fellowships
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资助金额:$45.79万
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财政年份:2013
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负责人:Prof Anthony Purcell
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依托单位:
Quantification of antigen presentation to CD8 T cells during virus infection
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批准号:nhmrc : 1023141
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项目类别:Project Grants
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资助金额:$38.81万
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财政年份:2012
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负责人:Prof Anthony Purcell
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依托单位:
A structural investigation into the adaptive immune response to a persistent and ubiquitous human virus
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批准号:nhmrc : 1009326
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项目类别:NHMRC Project Grants
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资助金额:$38.33万
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财政年份:2011
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负责人:Prof Anthony Purcell
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依托单位:
Biosynthesis, folding and modification of conotoxins
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批准号:DP110101331
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项目类别:Discovery Projects
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资助金额:$23.22万
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财政年份:2011
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负责人:Prof Anthony Purcell
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依托单位:
A protein molecular interaction and localization facility
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批准号:LE100100036
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$31.34万
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财政年份:2010
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负责人:Prof Anthony Purcell
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依托单位:
Mass spectrometry facility for the quantitation and analysis of post-translationally modified peptides
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批准号:LE0882913
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$20.0万
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财政年份:2008
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负责人:Prof Anthony Purcell
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 508926
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项目类别:NHMRC Research Fellowships
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资助金额:$44.38万
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财政年份:2008
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负责人:Prof Anthony Purcell
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依托单位:
An X-ray crystallographic investigation into the adaptive immune response to Epstein Barr Virus
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批准号:nhmrc : 491117
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项目类别:NHMRC Project Grants
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资助金额:$34.8万
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财政年份:2008
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负责人:Prof Anthony Purcell
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依托单位:
Remodelling of bacterial outer membranes: implications for vaccine development.
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批准号:nhmrc : 508911
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项目类别:NHMRC Project Grants
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资助金额:$37.22万
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财政年份:2008
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负责人:Prof Anthony Purcell
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依托单位:
Structural basis of influenza A virus-specific CD8+ T cell Receptor Diversity
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批准号:nhmrc : 350324
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项目类别:NHMRC Project Grants
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资助金额:$31.31万
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财政年份:2005
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负责人:Prof Anthony Purcell
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依托单位:
Antigen selection in the MHC-restricted cellular immune response
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批准号:nhmrc : 145636
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项目类别:NHMRC Project Grants
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资助金额:$11.71万
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财政年份:2001
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负责人:Prof Anthony Purcell
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依托单位:
国内基金
海外基金
基于短寿蛋白肿瘤疫苗诱导的抗瘤作用及其机制的研究
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批准号:30771999
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项目类别:面上项目
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资助金额:33.0万元
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批准年份:2007
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负责人:王立新
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依托单位: