Quantification of antigen presentation to CD8 T cells during virus infection

病毒感染期间 CD8 T 细胞抗原呈递的定量

• 批准号: nhmrc : 1023141
• 负责人: Prof Anthony Purcell
• 金额: $ 38.81万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/quantification-antigen-presentation-virus-infection/110248
• 关键词: Quantification; antigen; presentation; CD8; cells

Knowledge of how virus-infected cells are detected by the bodyÍs immune system is fundamental to our understanding of virus infections and attempts to improve vaccines. We know that many proteins are displayed during virus infection but until now, the precise details of this display have only been worked out for very few proteins, studied one at a time. In this project we will apply cutting-edge technology to gain the first holistic view of how a virus-infected cell looks to the immune system.

了解bodyÍs免疫系统如何检测受病毒感染的细胞是我们理解病毒感染和尝试改进疫苗的基础。我们知道许多蛋白质在病毒感染期间被展示出来，但直到现在，这种展示的精确细节只针对极少数蛋白质被研究出来，一次研究一个。在这个项目中，我们将应用尖端技术，首次全面了解病毒感染细胞对免疫系统的影响。