A study into post-translational modifications on adaptive immunity
A study into post-translational modifications on adaptive immunity
批准号:
DP150104503
负责人:
Prof Anthony Purcell
金额:
$29.13万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2018-02-20
中文摘要
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英文摘要
Using proteomics, structural biology and cellular immunology, this project aims to provide a greater understanding of the impact of PTMs on the immune system. The immune system combats pathogens by mounting T-cell responses against foreign antigens present in infected cells. However, T-cells activated by self-antigens that are inadvertently presented by healthy cells can cause aberrant T-cell reactivity and disease. Post-translational modifications (PTMs) are common in the host's proteins, but surprisingly little is known about their effect on T-cell immunity.
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Understanding the complexity of antigen presentation
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批准号:nhmrc : 1137739
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项目类别:Research Fellowships
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资助金额:$52.37万
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财政年份:2018
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负责人:Prof Anthony Purcell
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依托单位:
Understanding the complexity of antigen presentation
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批准号:nhmrc : GNT1137739
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项目类别:Research Fellowships
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资助金额:$77.45万
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财政年份:2018
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负责人:Prof Anthony Purcell
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依托单位:
Next Generation Mass Spectrometry for Analysis of Biomolecules
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批准号:LE160100193
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$39.34万
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财政年份:2016
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负责人:Prof Anthony Purcell
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依托单位:
Understanding determinant selection in autoimmune diseases
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批准号:nhmrc : 1044215
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项目类别:Research Fellowships
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资助金额:$45.79万
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财政年份:2013
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负责人:Prof Anthony Purcell
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依托单位:
Quantification of antigen presentation to CD8 T cells during virus infection
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批准号:nhmrc : 1023141
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项目类别:Project Grants
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资助金额:$38.81万
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财政年份:2012
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负责人:Prof Anthony Purcell
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依托单位:
Antigen presentation during HLA B27 associated auotimmune disease
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批准号:nhmrc : 1022509
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项目类别:Project Grants
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资助金额:$47.7万
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财政年份:2012
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负责人:Prof Anthony Purcell
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依托单位:
A structural investigation into the adaptive immune response to a persistent and ubiquitous human virus
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批准号:nhmrc : 1009326
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项目类别:NHMRC Project Grants
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资助金额:$38.33万
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财政年份:2011
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负责人:Prof Anthony Purcell
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依托单位:
Biosynthesis, folding and modification of conotoxins
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批准号:DP110101331
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项目类别:Discovery Projects
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资助金额:$23.22万
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财政年份:2011
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负责人:Prof Anthony Purcell
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依托单位:
A protein molecular interaction and localization facility
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批准号:LE100100036
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$31.34万
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财政年份:2010
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负责人:Prof Anthony Purcell
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依托单位:
Mass spectrometry facility for the quantitation and analysis of post-translationally modified peptides
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批准号:LE0882913
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$20.0万
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财政年份:2008
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负责人:Prof Anthony Purcell
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 508926
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项目类别:NHMRC Research Fellowships
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资助金额:$44.38万
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财政年份:2008
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负责人:Prof Anthony Purcell
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依托单位:
An X-ray crystallographic investigation into the adaptive immune response to Epstein Barr Virus
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批准号:nhmrc : 491117
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项目类别:NHMRC Project Grants
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资助金额:$34.8万
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财政年份:2008
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负责人:Prof Anthony Purcell
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依托单位:
Remodelling of bacterial outer membranes: implications for vaccine development.
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批准号:nhmrc : 508911
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项目类别:NHMRC Project Grants
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资助金额:$37.22万
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财政年份:2008
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负责人:Prof Anthony Purcell
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依托单位:
Structural basis of influenza A virus-specific CD8+ T cell Receptor Diversity
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批准号:nhmrc : 350324
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项目类别:NHMRC Project Grants
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资助金额:$31.31万
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财政年份:2005
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负责人:Prof Anthony Purcell
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依托单位:
Antigen selection in the MHC-restricted cellular immune response
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批准号:nhmrc : 145636
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项目类别:NHMRC Project Grants
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资助金额:$11.71万
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财政年份:2001
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负责人:Prof Anthony Purcell
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依托单位:
海外基金