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A study into post-translational modifications on adaptive immunity

A study into post-translational modifications on adaptive immunity
适应性免疫翻译后修饰的研究
批准号:
DP150104503
负责人:
Prof Anthony Purcell
金额:
$29.13万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2018-02-20

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中文摘要
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英文摘要
Using proteomics, structural biology and cellular immunology, this project aims to provide a greater understanding of the impact of PTMs on the immune system. The immune system combats pathogens by mounting T-cell responses against foreign antigens present in infected cells. However, T-cells activated by self-antigens that are inadvertently presented by healthy cells can cause aberrant T-cell reactivity and disease. Post-translational modifications (PTMs) are common in the host's proteins, but surprisingly little is known about their effect on T-cell immunity.
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  • 项目类别:
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  • 资助金额:
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  • 财政年份:
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  • 负责人:
    Prof Anthony Purcell
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Next Generation Mass Spectrometry for Analysis of Biomolecules
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