A study into post-translational modifications on adaptive immunity

适应性免疫翻译后修饰的研究

• 批准号: DP150104503
• 负责人: Prof Anthony Purcell
• 金额: $ 29.13万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-02-20
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150104503
• 关键词: study; into; post; translational; modifications

Using proteomics, structural biology and cellular immunology, this project aims to provide a greater understanding of the impact of PTMs on the immune system. The immune system combats pathogens by mounting T-cell responses against foreign antigens present in infected cells. However, T-cells activated by self-antigens that are inadvertently presented by healthy cells can cause aberrant T-cell reactivity and disease. Post-translational modifications (PTMs) are common in the host's proteins, but surprisingly little is known about their effect on T-cell immunity.

利用蛋白质组学、结构生物学和细胞免疫学，该项目旨在更好地了解PTMS对免疫系统的影响。免疫系统通过提高T细胞对感染细胞中存在的外来抗原的反应来对抗病原体。然而，被健康细胞无意中呈现的自身抗原激活的T细胞可能会导致异常的T细胞反应性和疾病。翻译后修饰(PTM)在宿主的蛋白质中很常见，但令人惊讶的是，人们对它们对T细胞免疫的影响知之甚少。