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Cryo-ultramicrotome for Bioimaging

用于生物成像的冷冻超薄切片机

基本信息

批准号：
390373-2010
负责人：
Wasteneys, Geoffrey
金额：
$ 10.92万
依托单位：
University of British Columbia
依托单位国家：
加拿大
项目类别：
Research Tools and Instruments - Category 1 (<$150,000)
财政年份：
2009
资助国家：
加拿大
起止时间：
2009-01-01 至 2010-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=443175
关键词：
Cryo ultramicrotome Bioimaging

项目摘要

The UBC Bioimaging Facility (BIF) is a microscopy resource facility with a strong training mandate. We require a cryo-ultramicrotome to improve both biological sample preparation for microscopy and the training of students and faculty at UBC. A cryo-ultramicrotome is specialized for cutting extremely thin slices of frozen biological material but is versatile in that it may also be used for conventionally prepared specimens. It is required for many types of sample preparation for both light microscopy and transmission electron microscopy. The BIF serves as both a service facility to which researchers bring their projects to have our technicians perform the work for them, and a resource facility where researchers come to be trained by our technicians to use the equipment to perform their own research. BIF houses the latest light microscope and transmission electron microscope technology and is experiencing a bottleneck with respect to sample preparation. We currently have one ultramicrotome. A new cryo-ultramicrotome will allow us to expand our current service to more researchers and to allow us to train more students and faculty to perform their own research. As well, a new cryo-ultramicrotome will expand our current expertise with respect to the growing field of imaging frozen biological samples. These samples are preserved in their native state without being subject to chemical fixatives and therefore the samples are artifact-free. BIF currently houses some of the latest technology for imaging frozen samples and the BIF staff are international known for their expertise in this field. A new cryo-ultramicrotome in the BIF will reinforce and enhance our expertise and augment research output at UBC.

UBC生物成像设施（BIF）是一个具有强大培训任务的显微镜资源设施。我们需要一个冷冻超薄切片机，以改善生物样品制备显微镜和学生和教师在UBC的培训。冷冻超薄切片机专门用于切割冷冻生物材料的极薄切片，但其用途广泛，因为其也可用于常规制备的标本。光学显微镜和透射电子显微镜的许多类型的样品制备都需要它。 BIF既是一个服务设施，研究人员可以将他们的项目带到这里，让我们的技术人员为他们执行工作，也是一个资源设施，研究人员可以通过我们的技术人员进行培训，使用设备进行自己的研究。 BIF拥有最新的光学显微镜和透射电子显微镜技术，并且在样品制备方面遇到了瓶颈。我们现在有一台超薄切片机。一个新的冷冻超薄切片机将使我们能够扩大我们目前的服务，以更多的研究人员，并使我们能够培训更多的学生和教师进行自己的研究。此外，一种新的冷冻超薄切片机将扩大我们目前的专业知识，在不断增长的冷冻生物样品成像领域。这些样品以天然状态保存，不受化学固定剂的影响，因此样品不含人工制品。 BIF目前拥有一些最新的冷冻样品成像技术，BIF的工作人员以其在该领域的专业知识而闻名。在BIF的一个新的冷冻超薄切片机将加强和提高我们的专业知识，并增加在UBC的研究成果。