Molecular genetic analysis of drosophila disconnected gene during development

果蝇发育过程中断开基因的分子遗传学分析

• 批准号: 121815-2007
• 负责人: Campos, Ana
• 金额: $ 3.28万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=451597
• 关键词: Molecular; genetic; analysis; drosophila; disconnected

The Drosophila disconnected (disco) gene encodes a C2H2 type zinc finger transcription factor required for the development of central and peripheral nervous system. disco expression during development is dynamic, suggesting a role for this gene in a variety of developmental processes. During the previous funding period we have investigated a novel function for disco in the patterning of Proximal -Distal (P-D) axis during leg and antennal development. The P-D axis refers to the way insect appendages (or limbs) are organized from the portion closest to the body (proximal) to the structures that make the ti[p of the appendage. In vertebrates as well as insects the Distal-less (Dll) gene represents the master regulator of this important developmental process.

果蝇断开（disco）基因编码C2H2型锌指转录因子，这是中枢和周围神经系统发育所必需的。Disco在发育过程中的表达是动态的，表明该基因在多种发育过程中发挥作用。在之前的资助期间，我们研究了disco在腿和触角发育期间近端-远端（P-D）轴模式中的新功能。p - d轴指的是昆虫附属物（或四肢）的组织方式，从最接近身体的部分（近端）到构成附属物ti[p]的结构。在脊椎动物和昆虫中，远端缺失（Dll）基因是这一重要发育过程的主要调控因子。