Genetic analysis of larval behaviour

幼虫行为的遗传分析

• 批准号: 121815-2012
• 负责人: Campos, Ana
• 金额: $ 2.04万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=545369
• 关键词: Genetic; analysis; larval; behaviour

The fruit fly Drosophila is an excellent model to study the genetic basis of behaviour and homeostasis. Its genome, less complex than that of vertebrates, facilitates a mutational approach to a wide range of questions. Drosophila as all other organisms continually modulates food intake and metabolism to energy needs and nutrient availability. The current model in the literature assigns the fat body, the Drosophila adipose tissue that performs multiple metabolic functions, with a central role in the coordination of behaviour and homeostasis. Our work places the conserved scaffold protein RanBPM as an important contributor of the fat body function in these processes.

果蝇是研究行为和动态平衡遗传基础的极好模型。它的基因组没有脊椎动物那么复杂，有助于用突变的方法解决广泛的问题。果蝇就像所有其他生物一样，不断地调节食物的摄取和新陈代谢，以满足能量需求和营养供应。目前文献中的模型指定脂肪体，即执行多种新陈代谢功能的果蝇脂肪组织，在协调行为和动态平衡方面发挥中心作用。我们的工作将保守的支架蛋白RanBPM作为脂肪身体功能的重要贡献者。