Molecular genetic analysis of drosophila disconnected gene during development

果蝇发育过程中断开基因的分子遗传学分析

• 批准号: 121815-2007
• 负责人: Campos, Ana
• 金额: $ 3.28万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=475606
• 关键词: Molecular; genetic; analysis; drosophila; disconnected

The Drosophila disconnected (disco) gene encodes a C2H2 type zinc finger transcription factor required for the development of central and peripheral nervous system. disco expression during development is dynamic, suggesting a role for this gene in a variety of developmental processes. During the previous funding period we have investigated a novel function for disco in the patterning of Proximal -Distal (P-D) axis during leg and antennal development. The P-D axis refers to the way insect appendages (or limbs) are organized from the portion closest to the body (proximal) to the structures that make the ti[p of the appendage. In vertebrates as well as insects the Distal-less (Dll) gene represents the master regulator of this important developmental process.

Drosophila disconnected（disco）基因编码一个C2 H2型锌指转录因子，是中枢和外周神经系统发育所必需的。 在发育过程中，disco的表达是动态的，表明该基因在多种发育过程中发挥作用。在上一个资助期间，我们研究了迪斯科在腿和触角发育过程中近端-远端（P-D）轴模式中的一种新功能。P-D轴是指昆虫附肢（或肢体）从最靠近身体（近侧）的部分到构成附肢的结构的组织方式。在脊椎动物以及昆虫中，Distal-less（Dll）基因代表了这一重要发育过程的主调节因子。