Frequency domain mode locked novel dual core fiber laser for multichannel array based doppler optical coherence tomography

光学相干断层扫描（OCT）是一种新的成像模式，它提供了适用于实时成像的高分辨率（接近细胞水平），并可用于对视网膜和其他器官进行肿瘤和血管病变成像。多普勒OCT（DOCT）增加了血流成像能力，其对微循环中的缓慢血流敏感，并且已经显示出检测癌前和癌性病症中的新血管。 近来，人们对高功率包层泵浦光纤激光器（例如掺Yb光纤激光器）作为传统激光器的替代物越来越感兴趣。 这种光纤激光器的频域锁模可以在1027-1105 nm的波长范围内为DOCT提供最佳光源，最适合于对生物组织进行成像。 我们将开发一种低成本和低维护的Yb掺杂光纤激光器，用于基于多通道阵列的DOCT，这对于指导下一代基于激光的治疗（如双光子光动力学治疗）非常有用，并提供严格控制的损伤半径以保护正常组织。

Optical Coherence Tomography (OCT) is a new imaging modality that provides high resolution (near cellular level) suitable for real-time imaging and is becoming available for imaging the retina and other organs for neoplastic and vascular lesions. Doppler OCT (DOCT) adds blood flow imaging capability which is sensitive to slow blood flow in the microcirculation, and has been shown to detect neovasculature in pre-cancer and cancerous conditions. Recently there has been a growing interest in high power cladding pumped fiber lasers such as Yb doped fiber lasers, as a replacement for conventional lasers. Frequency domain mode locking of such fiber lasers may provide an optimal light source for DOCT at a wavelength range of 1027-1105 nm, optimal for imaging biological tissues. We will develop a low-cost and low-maintenance Yb doped fiber laser for multichannel array based DOCT, which could be extremely useful for guiding the next generation laser-based treatments, such as 2-photon photodynamic therapy, and provide a tightly controlled damage radius to preserve normal tissue.