Frequency domain mode locked novel dual core fiber laser for multichannel array based doppler optical coherence tomography

光学相干层析成像(OCT)是一种新的成像方式，它提供高分辨率(接近细胞水平)，适合实时成像，并可用于对视网膜和其他器官的肿瘤和血管病变进行成像。多普勒OCT(DOCT)增加了对微循环中缓慢血流敏感的血流成像能力，并已被证明可以检测癌症前期和癌症条件下的新生血管。近年来，人们对高功率包层泵浦光纤激光器(如掺Yb光纤激光器)作为常规激光器的替代品的兴趣与日俱增。这种光纤激光器的频域锁模可以在1027-1105 nm的波长范围内为DOCT提供最佳光源，对于生物组织成像是最佳的。我们将开发一种用于基于多通道阵列的DOCT的低成本、低维护的掺Yb光纤激光器，这将对指导下一代基于激光的治疗(如双光子光动力学治疗)非常有用，并提供严格控制的损伤半径以保护正常组织。

Optical Coherence Tomography (OCT) is a new imaging modality that provides high resolution (near cellular level) suitable for real-time imaging and is becoming available for imaging the retina and other organs for neoplastic and vascular lesions. Doppler OCT (DOCT) adds blood flow imaging capability which is sensitive to slow blood flow in the microcirculation, and has been shown to detect neovasculature in pre-cancer and cancerous conditions. Recently there has been a growing interest in high power cladding pumped fiber lasers such as Yb doped fiber lasers, as a replacement for conventional lasers. Frequency domain mode locking of such fiber lasers may provide an optimal light source for DOCT at a wavelength range of 1027-1105 nm, optimal for imaging biological tissues. We will develop a low-cost and low-maintenance Yb doped fiber laser for multichannel array based DOCT, which could be extremely useful for guiding the next generation laser-based treatments, such as 2-photon photodynamic therapy, and provide a tightly controlled damage radius to preserve normal tissue.