Freeze-dryer for functional and bioactive biproducts

用于功能性和生物活性副产品的冷冻干燥机

• 批准号: 407893-2011
• 负责人: Moresoli, Christine
• 金额: $ 8.18万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=472742
• 关键词: Freeze; dryer; functional; bioactive; biproducts

The research activities of the applicants for this equipment include biotechnology and materials for the production of therapeutic proteins, virus products, protein food ingredients and biocomposite materials for automotive applications. These applications require the availability of significant quantities of stable bioproducts over long periods of time. The drying of bioproducts allows their storage for prolonged periods of time. A freeze-drying system is a mild drying operation that avoids the use of air and high temperatures which is advantageous for bioproducts because it preserves the quality of these products. The principle of operation consists of an initial freezing of the product with subsequent removal of the water from the product by using a very low pressure that leads to the vaporization of the frozen water. This approach is unique in that there is very little movement of water within the bioproduct to be frozen. The significant costs due to the low pressure required and the long time required to achieve the drying require a reliable vacuum pump and a precise control of the individual steps leading to the drying of the bioproducts.

该设备的申请人的研究活动包括生物技术和用于生产治疗性蛋白质、病毒产品、蛋白质食品成分和汽车应用的生物复合材料的材料。这些应用需要在长时间内获得大量稳定的生物产品。生物制品的干燥允许其长时间储存。冷冻干燥系统是一种温和的干燥操作，避免使用空气和高温，这对生物产品是有利的，因为它保留了这些产品的质量。 操作原理包括产品的初始冷冻，随后通过使用导致冷冻水蒸发的非常低的压力从产品中除去水。这种方法的独特之处在于，在待冷冻的生物产品中几乎没有水的运动。由于所需的低压和实现干燥所需的长时间而导致的显著成本需要可靠的真空泵和导致生物产品干燥的各个步骤的精确控制。