Freeze Dryer for Research in Materials and Biological Chemistry

用于材料和生物化学研究的冷冻干燥机

• 批准号: RTI-2017-00031
• 负责人: MacLachlan, Mark
• 金额: $ 10.91万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=616528
• 关键词: Freeze; Dryer; Research; Materials; Biological

We urgently need funding for a freeze dryer to support active research programs in materials science, biological chemistry, and analytical chemistry. Freeze drying, or lyophilization, is a dehydration technique that facilitates the removal of water or solvents under a vacuum from previously frozen samples. Freeze drying is generally employed for the concentration of temperature-sensitive compounds and for the preservation of biological products such as enzymes, strains of microorganisms, and environmental samples. For materials characterization, freeze drying is a critical step for preserving porosity in materials and enabling visualization of the structure by electron microscopy and other techniques. Significant new discoveries are anticipated using the freeze dryer, such as the development of catalytic nanomaterials supported on chitin nanocrystal aerogels, new drugs for treating Alzheimer's, and a better understanding of the formation of ice crystals on aerosol particles in the atmosphere. The freeze dryer will be situated in the Biological Research Facility (BioServices) in the Chemistry Department at UBC. BioServices is a facility entirely devoted to offering comprehensive biological research support customized to the specific needs of interdisciplinary research programs in chemistry. The facility is specially designed for molecular and cell biology research and certified for work with Class II biohazard pathogens. Placing the freeze dryer in this well-supported facility will ensure that it is available to numerous NSERC-funded researchers. As well, the full-time staff in the facility have extensive experience working with freeze dryers and related equipment, and will be able to ensure proper maintenance of the equipment. The freeze dryer is critical to the training of our HQP. Grad students, undergrad students, and post-docs will obtain hands-on training with the freeze dryer from the staff in the BioServices facility (who have more than 30 years of experience with freeze dryers) to prepare aerogels, porous cellulosic materials, porous chitin materials, and compounds for important studies in the areas of protein chemistry, anticancer compound discovery, antibiotics, enzymes, high-throughput screening, nanomechanical devices, and biomedical applications.

我们迫切需要资金用于冷冻干燥机，以支持材料科学，生物化学和分析化学的积极研究计划。冷冻干燥或冻干是一种脱水技术，有助于在真空下从先前冷冻的样品中除去水或溶剂。冷冻干燥通常用于 温度敏感化合物的浓度，以及 生物制品如酶的保存， 微生物菌株和环境样品。对于材料表征，冷冻干燥是保持材料孔隙率并通过电子显微镜和其他技术实现结构可视化的关键步骤。预计使用冷冻干燥机将有重大的新发现，例如开发甲壳素凝胶支撑的催化纳米材料，治疗阿尔茨海默氏症的新药，以及更好地了解大气中气溶胶颗粒上冰晶的形成。 冻干机将位于UBC化学系的生物研究机构（BioServices）。BioServices是一家完全致力于提供全面 生物研究支持定制的具体需求， 化学的跨学科研究项目。该设施是 专为分子和细胞生物学研究而设计， 第二类生物危害病原体将冻干机放置在这个支持良好的设施中将确保它可供众多NSERC资助的研究人员使用。此外，该设施的全职工作人员具有使用冻干机和相关设备的丰富经验，并将能够确保设备的适当维护。 冻干机对我们的HQP培训至关重要。格拉德研究生、本科生和博士后将从BioServices机构的工作人员那里获得冻干机的实践培训（拥有超过30年的冷冻干燥机经验）来制备气凝胶、多孔纤维素材料、多孔几丁质材料和化合物，用于蛋白质化学、抗癌化合物发现、抗生素、酶、高通量筛选、纳米机械装置和生物医学应用。