Biointerface science: proteoglycan 4 (PRG4) with and without hyaluronic acid as a novel ocular surface boundary lubricant & contact lens coating

生物界面科学：含或不含透明质酸的蛋白聚糖 4 (PRG4) 作为新型眼表边界润滑剂

• 批准号: 413685-2012
• 负责人: Schmidt, Tannin
• 金额: $ 4.5万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=503837
• 关键词: Biointerface; science; proteoglycan; PRG4; without

Dry eye disease is a major health-care issue and drain on health-care resources worldwide, with symptoms of discomfort, damage to the ocular surface, and a significant reduction in quality of life, with no current therapeutically effective treatments. Cells at the ocular surface, which forms a biointerface when sliding against an opposing tissue or contact lens, are subject to significant friction forces generated with eyelid blinking. These forces can be exacerbated by contact lens wear particularly in the presence of a compromised tear film, another symptom of dry eye. Proteoglycan 4 (PRG4), also known as lubricin, is a protein originally discovered in synovial fluid and on the surface of articular cartilage that has recently been discovered at the ocular surface. PRG4 has been shown to function in a dose-dependent manner, both alone and in combination with hyaluronic

干眼症是一个主要的卫生保健问题，消耗了全世界的卫生保健资源，具有不适症状、眼表损伤和生活质量显著降低，目前没有治疗有效的治疗方法。当抵靠相对的组织或接触透镜滑动时，眼表面处的细胞形成生物界面，其经受眼睑眨眼产生的显著摩擦力。隐形透镜的佩戴会加剧这些力，特别是在泪膜受损的情况下，这是干眼的另一种症状。蛋白聚糖4（PRG 4），也称为润滑素，是一种最初在滑液和关节软骨表面发现的蛋白质，最近在眼表面发现。PRG4已经显示出以剂量依赖性方式起作用，无论是单独的还是与透明质酸结合的。