Inference and variable selection in semiparametric survival models with censored or missing data

具有删失或缺失数据的半参数生存模型中的推理和变量选择

• 批准号: 261567-2013
• 负责人: Lu, Xuewen
• 金额: $ 1.09万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=525286
• 关键词: Inference; variable; selection; semiparametric; survival

Millions of people are killed by cancer each year. There are evidences that the survival time of cancer patients depends on many risk factors. Some of the risk factors are obvious and well studied, e.g. smoke habits and alcohol abuse, while many others are hidden in the human's genes and DNAs, which are not easy to observe and handle. In recent years, breakthroughs in biomedical technology have made it possible to obtain hundreds of thousands of gene expression measurements, along with the clinical information about the survival outcomes of patients. In this case, researchers and practitioners are interested in (1) identifying features (or genes, covariates) that are associated with survival, so that they can examine their precise roles, and (2) developing a multivariate model for the relationship between the features and the survival time that can be used to predict survival in a new observation and to identify better treatment strategies for cancers.

每年有数百万人死于癌症。 有证据表明，癌症患者的生存时间取决于许多危险因素。一些风险因素是显而易见的，并得到了充分的研究，例如吸烟习惯和酗酒，而其他许多风险因素隐藏在人类的基因和DNA中，不容易观察和处理。近年来，生物医学技术的突破使人们有可能获得数十万个基因表达测量值，沿着有关患者生存结果的临床信息。在这种情况下，研究人员和从业者感兴趣的是（1）识别与生存相关的特征（或基因，协变量），以便他们可以检查它们的确切作用，以及（2）开发特征与生存时间之间关系的多变量模型，可用于预测新观察中的生存率，并确定更好的癌症治疗策略。