Construction and analysis of synthetic eukaryotic gene regulatory networks

合成真核基因调控网络的构建与分析

• 批准号: 313172-2011
• 负责人: Kaern, Mads
• 金额: $ 2.91万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=526631
• 关键词: Construction; analysis; synthetic; eukaryotic; gene

The term "synthetic biology" is used to describe a field of research at the interface between disciplines ranging from applied mathematics and physical biology to molecular genetics and systems biology. The central dogma of the field is based on a principle of reverse engineering: optimal insight into the operation and design principles of a complex system can be gained by breaking the system into smaller parts, characterizing these parts in isolation, and reassembling them to understand how they work together. However, synthetic biology research does not limit itself to the study of natural systems. Rather, it explicitly seeks to create artificial systems that endow living organisms with novel functionalities. This biological systems engineering is based on the premise that DNA-encoded "parts" can be isolated and assembled into functional "devices", which, in turn, can be combined into larger circuits.

“合成生物学”一词用于描述从应用数学和物理生物学到分子遗传学和系统生物学等学科之间的研究领域。该领域的核心原则是基于逆向工程的原则：通过将系统分解成更小的部分，孤立地描述这些部分的特征，并将它们重新组装以了解它们如何协同工作，可以获得对复杂系统的操作和设计原则的最佳洞察。然而，合成生物学的研究并不局限于对自然系统的研究。相反，它明确地寻求创造人工系统，赋予生物体新的功能。这种生物系统工程的前提是，dna编码的“部件”可以被分离并组装成功能性的“设备”，而这些“设备”又可以组合成更大的电路。