Numerical models and methods for cell image analysis

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Common diseases such as stroke, diabetes, asthma, and cancer result in substantial health care expenditure in Canada every year. These diseases are often caused by environmental factors interacting with genetically susceptible individuals. Understanding how the regulatory gene networks affect cell function will facilitate treatment of common disorders. However, linking genes, diseases, and treatments is time-consuming. This involves collection of massive amounts of data from native and genetically perturbed cells. The recent DNA microarray technology allows cell biologists to quickly record cell activities by high-throughput real-time imaging systems. With thousands of images generated in each experiment, the traditional manual or interactive computer-assisted tracking would no longer be feasible. Efficient and reliable software for tracking cellular behaviour becomes critical in analyzing the cell images.