Characterization and optimization of bioactive coatings for vascular applications

血管应用生物活性涂层的表征和优化

• 批准号: 298225-2010
• 负责人: Lerouge, Sophie
• 金额: $ 1.46万
• 依托单位: École de technologie supérieure
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=548269
• 关键词: Characterization; optimization; bioactive; coatings; vascular

Cardiovascular diseases are the most important cause of morbidity and mortality in industrialised countries like Canada. Minimally-invasive therapies using endovascular implants inserted by catheters have been developed that offer numerous advantages over conventional surgeries, including reduced risks of mortality, decreased blood loss and shorter recovery and hospitalisation times. Yet, their efficacy is often jeopardized by frequent clinical complications. As chairman of the Canada Research Chair in Biomaterials and endovascular implants, Lerouge aims to improve these implants and therapies by developing clinically-suitable strategies. This research program is focused on bioactive coatings designed to counter the inherent shortcomings of synthetic polymers used for endovascular implants. Our approach is to develop a versatile method using plasma-polymerized coatings that can be deposited on a wide variety of surfaces. These films were shown to exhibit excellent cell adhesion properties. More importantly, their chemical composition allows easy and efficient immobilisation of biomolecules for the control of the biological response. Yet several issues (adhesion, sterilizability, stability ...) remain to be addressed before transfering these innovative coatings onto realistic implants. This research program will enable optimization and characterization of bioactive coatings for a new generation of vascular and endovascular implants with less clinical complications. The engineering tools and methods developed will later also be applicable to other coatings and pathologies. Benefits will include multidisciplinary training of highly qualified personnel in this very strategic research field for Canada. Lerouge's close collaborations with clinicians and industry in this strategically-important field for Canada constitute keys for success.

心血管疾病是加拿大等工业化国家发病和死亡的最重要原因。已经开发了使用通过导管插入的血管内植入物的微创治疗，其提供了许多优于传统手术的优点，包括降低死亡风险、减少失血以及缩短恢复和住院时间。然而，它们的疗效往往受到频繁的临床并发症的危害。作为加拿大生物材料和血管内植入物研究主席，Lerouge的目标是通过制定临床适用的策略来改善这些植入物和治疗。该研究项目的重点是生物活性涂层，旨在克服用于血管内植入物的合成聚合物的固有缺点。我们的方法是开发一种使用等离子体聚合涂层的通用方法，该方法可以沉积在各种各样的表面上。这些膜显示出优异的细胞粘附性能。更重要的是，它们的化学组成允许容易和有效地固定生物分子，以控制生物反应。然而，一些问题（粘附性、可灭菌性、稳定性.）在将这些创新的涂层转移到实际的植入物上之前仍然需要解决。该研究计划将使新一代血管和血管内植入物的生物活性涂层的优化和表征具有更少的临床并发症。开发的工程工具和方法以后也将适用于其他涂层和病理学。好处将包括在加拿大这一非常战略性的研究领域对高素质人员进行多学科培训。Lerouge与临床医生和行业在这一具有重要战略意义的领域的密切合作是加拿大成功的关键。