The genetic analysis of autophagy-dependent caspase activity in drosophila

果蝇自噬依赖性 caspase 活性的遗传分析

• 批准号: 312471-2010
• 负责人: Reed, Bruce
• 金额: $ 1.97万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=548751
• 关键词: genetic; analysis; autophagy; dependent; caspase

Autophagy is a normal cellular process that is required for the disposal and recycling of large proteins or damaged organelles. When cells are starved they can respond by turning on their autophagy machinery, which liberates nutrients and promotes cell survival. Large groups of cells, and sometimes entire tissues, are eliminated by programmed cell death during the embryonic development of multicellular organisms. It is not unusual for such cells to also up-regulate autophagy - although in this case autophagy may actually be functioning to promote cell death.

自噬是一种正常的细胞过程，需要处理和回收大蛋白质或受损的细胞器。 当细胞饥饿时，它们可以通过开启自噬机制来做出反应，从而释放营养物质并促进细胞存活。 在多细胞生物的胚胎发育过程中，大量细胞，有时是整个组织，通过程序性细胞死亡而被消除。 这类细胞也上调自噬并不罕见-尽管在这种情况下，自噬实际上可能起到促进细胞死亡的作用。