Probing membrane transport using plasmonic nanoarrays engineered for surface-enhanced spectroscopies

使用专为表面增强光谱设计的等离子体纳米阵列探测膜传输

• 批准号: 386427-2010
• 负责人: Brosseau, Christa
• 金额: $ 2.33万
• 依托单位: Saint Mary's University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=550420
• 关键词: Probing; membrane; transport; using; plasmonic

This research proposal seeks to develop a novel tool for the investigation of electric field-driven membrane transport phenomena, based on nanoparticle plasmonics and surface-enhanced vibrational spectroscopies. This research will be utilized to probe a variety of voltage-gated membrane transport processes, with an emphasis on biomimetic membrane systems. Of particular interest is the degree to which protein aggregates, such as amyloids, interact with biomembrane systems, and what kind of channels are formed as a result of this interaction. Other systems of interest include the transduction of particular protein toxins across membrane systems, and a better understanding of small molecule permeation through pre-existing protein transmembrane channels.

该研究计划旨在开发一种基于纳米粒子等离子体激元和表面增强振动光谱的新型工具，用于研究电场驱动的膜传输现象。这项研究将用于探测各种电压门控膜传输过程，重点是仿生膜系统。特别令人感兴趣的是蛋白质聚集体（例如淀粉样蛋白）与生物膜系统相互作用的程度，以及这种相互作用形成的通道类型。其他感兴趣的系统包括特定蛋白质毒素跨膜系统的转导，以及更好地了解小分子通过预先存在的蛋白质跨膜通道的渗透。