Innovative Plasmonic Platforms for Advanced Molecular Sensing

用于先进分子传感的创新等离子体平台

• 批准号: RGPIN-2016-04202
• 负责人: Brosseau, Christa
• 金额: $ 2.62万
• 依托单位: Saint Mary's University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=686673
• 关键词: Innovative; Plasmonic; Platforms; Advanced; Molecular

The present research proposal seeks to focus on an area of nanotechnology termed plasmonics. The field of plasmonics relies on the unique optical and electronic effects observed when certain nanoscale metals, such as the coinage metals, interact with incident electric fields, such as the electric field component of light. Such interaction generates what are termed surface plasmons, which can be either confined to the surface or can propagate along the surface of a nanometal, depending on its size and dimensions. These surface plasmons have remarkable attributes, most notably the ability to harvest and manipulate light at the nanoscale, leading to highly sensitive chemical sensing and unprecedented future developments in near-field optical microscopy and plasmonic circuitry. Such advanced materials have an enormous range of possible and demonstrated applications, ranging from enhanced solar-energy conversion to superlenses and optical cloaking. The research program outlined herein revolves around three main themes related to advanced molecular sensing using innovative plasmonic platforms: (i) enhanced sensitivity (ii) improved selectivity and (iii) future sustainability; these areas are summarized below.***(i) Enhanced sensitivity. While theoretical studies have demonstrated that the excellent light-manipulation of plasmonic nanoparticles should allow for single molecule level detection; routine evidence of such detection limits is lacking. A solution to this problem lies in the ability to not only fabricate nanoparticles with excellent monodispersity in terms of size and shape, but also in the ability to fabricate assemblies of such structures in a desired configuration over large surface areas with minimal cost. Our approach to overcome these issues will be to explore several strategies including layer-by-layer deposition, bioscaffolding and plasmonic metamolecular arrays for creating novel plasmonic platforms. ******(ii) Enhanced selectivity. One problem that continually plagues advances in plasmonic sensing is the non-specific interaction of non-target analytes with the sensor surface. Our approach will be to expand on our exploratory work in the field of aptasensors for target analyte detection. In addition, we will explore the extent to which electrochemical surface enhanced Raman spectroscopy (SERS) can be used to enhance selectivity. ******iii) Future sustainability. Current plasmonic metals, such as Au and Ag, suffer from the disadvantage of high cost, especially for gold, as well as limited long term availability, especially for silver. As part of this program, we plan to explore the use of copper and aluminum nanoparticles for plasmonic applications. Issues associated with the synthesis and stability of such nanostructures will be circumvented using methods such as ionic liquid stabilized nanoparticle synthesis and electrochemical deposition. ***********

目前的研究建议旨在集中在一个领域的纳米技术称为等离子体。等离子体激元领域依赖于当某些纳米级金属（例如钴金属）与入射电场（例如光的电场分量）相互作用时观察到的独特光学和电子效应。这种相互作用产生所谓的表面等离子体激元，其可以被限制在表面或可以沿着纳米金属的表面传播，这取决于其大小和尺寸。这些表面等离子体具有显着的属性，最值得注意的是在纳米级上捕获和操纵光的能力，导致高灵敏度的化学传感和近场光学显微镜和等离子体电路的前所未有的未来发展。这种先进材料有着广泛的可能和已证实的应用，从增强太阳能转换到超级透镜和光学隐身。 本文概述的研究计划围绕与使用创新等离子体平台的先进分子传感相关的三个主要主题：（i）增强灵敏度（ii）提高选择性和（iii）未来的可持续性;这些领域总结如下。(i)提高敏感性。虽然理论研究已经证明，等离子体纳米颗粒的出色的光操纵应该允许单分子水平的检测;缺乏这种检测极限的常规证据。该问题的解决方案在于不仅能够制造在尺寸和形状方面具有优异的单分散性的纳米颗粒，而且能够以最小的成本在大的表面积上以期望的配置制造这种结构的组件。我们的方法来克服这些问题将探索几种策略，包括逐层沉积，生物支架和等离子体元分子阵列，用于创建新的等离子体平台。**（二）提高选择性。持续困扰等离子体感测进展的一个问题是非目标分析物与传感器表面的非特异性相互作用。 我们的方法将是扩大我们的探索性工作，在该领域的适体传感器的目标分析物检测。此外，我们将探讨在何种程度上电化学表面增强拉曼光谱（Sers）可以用来提高选择性。* ㈢未来的可持续性。目前的等离子体金属，例如Au和Ag，具有高成本的缺点，特别是对于金，以及有限的长期可用性，特别是对于银。作为该计划的一部分，我们计划探索使用铜和铝纳米粒子的等离子体应用。 与这种纳米结构的合成和稳定性相关的问题将使用诸如离子液体稳定的纳米颗粒合成和电化学沉积的方法来规避。***********