Cell Production Augmentation Techniques

细胞产量增强技术

• 批准号: 463108-2014
• 负责人: McEachern, Cam
• 金额: $ 1.82万
• 依托单位: St. Lawrence College
• 依托单位国家: 加拿大
• 项目类别: Applied Research and Development Grants - Level 1
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=558250
• 关键词: Cell; Production; Augmentation; Techniques

Regenerative medicine involving the transplantation of cell-based implants holds great promise for improving the clinical efficacy of conventional treatments. This is possible because the implantation of repair-specific cells (such as stem cells) have the ability to restore tissue to normal function. The current procedures to create cell-based products are all manual in nature and hence do not enable high reproducibility and cost-effectiveness. Automated production could potentially be achieved through the robotic duplication of manual actions; however, the general industry challenge is that existing robotic systems for basic cell culture are highly complex, require significant space for operation, and require a high capital equipment investment. Octane Biotechs challenge is to develop an innovative, cost-effective and automated bioreactor-based system to meet the clinical production challenges.

再生医学涉及基于细胞的植入物的移植，对提高常规治疗的临床疗效有很大的希望。这是可能的，因为植入修复特异性细胞（如干细胞）具有恢复组织正常功能的能力。目前制造基于细胞的产品的程序本质上都是手动的，因此不能实现高可重复性和成本效益。自动化生产可以通过机器人复制人工操作来实现；然而，普遍的行业挑战是，现有的基本细胞培养机器人系统非常复杂，需要大量的操作空间，并且需要高资本设备投资。Octane biotechnologies面临的挑战是开发一种创新的，具有成本效益的自动化生物反应器系统，以满足临床生产的挑战。