New approaches to multiplexed protein profiling of complex samples with ultrahigh sensitivity

具有超高灵敏度的复杂样品多重蛋白质分析的新方法

• 批准号: 341375-2011
• 负责人: Juncker, David
• 金额: $ 3.28万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=572238
• 关键词: New; approaches; multiplexed; protein; profiling

The diagnosis of diseases relies on advanced technologies for detecting minute amounts of antigens in the blood. However, current analytical techniques are not sufficiently sensitive to use them for early disease detection in the case of cancer and other complex diseases. Here, we propose to develop new approaches for extending the limits of detection of analytical techniques. Success will allow to find new biomakers for disease, and eventually may pave the way to new diagnostic devices for use in research and in disease diagnosis and management.

疾病的诊断依赖于检测血液中微量抗原的先进技术。然而，目前的分析技术不够灵敏，无法在癌症和其他复杂疾病的情况下用于早期疾病检测。在这里，我们建议开发新的方法来扩大分析技术的检测范围。成功将使人们能够找到新的疾病生物制剂，并最终可能为用于研究和疾病诊断和管理的新诊断设备铺平道路。