Design, fabrication, and characterization of high surface area ion-selective electrodes for biosensing

用于生物传感的高表面积离子选择性电极的设计、制造和表征

• 批准号: 483884-2015
• 负责人: Soleymani, Leyla
• 金额: $ 1.82万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=583972
• 关键词: Design; fabrication; characterization; surface; area

Point-of-care disease management systems that enable complex laboratory testing to be performed at or near patients' locations have the potential to significantly improve the quality of healthcare by expediting clinical decision making and providing effective disease screening and diagnostics capabilities to people living in remote and resource-poor regions. ChroMedX is a Toronto-based biotechnology company that is working towards developing the first handheld point-of-care diagnostic system that combines co-oximetry for evaluating the body's oxygenation state with blood gas and electrolyte analysis. This system requires optical sample holders and electrochemical analyzers to be manufactured on the same platform. Although ChroMedX has substantial expertise in the design of optical systems and ion-selective membranes for blood electrolyte selection, they require additional expertise in developing miniaturized and high surface area electrochemical circuitry directly on their optical sample holder. Towards this goal, the industry and academic groups will collaborate to develop low-temperature, inexpensive, and scalable fabrication techniques for creating high surface area electrodes integrated with ion-selective membranes on flexible polymer substrates. Throughout this project, the developed manufacturing processes will be used to demonstrate blood electrolyte analysis using a miniaturized high surface area electrode system, which is integratable with ChroMedX's optical sample holder.

床旁疾病管理系统，使复杂的实验室检测能够在 患者的位置有可能通过加快临床治疗， 决策和提供有效的疾病筛查和诊断能力， 偏远和资源贫乏的地区。ChroMedX是一家总部位于多伦多的生物技术公司， 致力于开发第一个手持式护理点诊断系统，该系统结合了用于 通过血气分析和电解质分析评价机体的氧合状态。该系统需要光学 样品架和电化学分析仪在同一平台上制造。虽然ChroMedX 在光学系统和血液电解质离子选择膜的设计方面具有丰富的专业知识 选择，他们需要额外的专业知识，在开发小型化和高表面积电化学 直接安装在光学样品保持器上。为了实现这一目标，工业界和学术团体将 合作开发低温、廉价和可扩展的制造技术， 在柔性聚合物基底上与离子选择性膜集成的表面积电极。在整个 在本项目中，开发的制造工艺将用于证明血液电解质分析 使用小型化的高表面积电极系统，该系统可与ChroMedX的光学样品集成 保持器。