Mechanisms of human skeletal muscle remodelling with exercise

运动重塑人体骨骼肌的机制

• 批准号: RGPIN-2015-04251
• 负责人: Moore, Daniel
• 金额: $ 2.11万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=589684
• 关键词: Mechanisms; human; skeletal; muscle; remodelling

Skeletal muscle is an incredibly plastic tissue resulting from its remarkable ability to break down old and/or damaged proteins and make (synthesize) new functional ones. These processes occur simultaneously and continuously, are enhanced in response to exercise and nutrition, and ultimately function to ‘remodel’ this important tissue. The synthesis of new muscle proteins (MPS) significantly determines whether a muscle gets bigger and stronger, such as with resistance exercise (REX) through the synthesis of force-generating myofibrillar (MYO) proteins, and/or develop a greater endurance capacity, such as with endurance exercise (END) through the synthesis of energy-producing mitochondrial (MITO) proteins.

骨骼肌是一种令人难以置信的塑料组织，其出色的能力分解了旧和/或受损的蛋白质并制造（合成）新功能的蛋白质。这些过程简单而连续地发生，响应于运动和营养而增强，并最终起作用以“重塑”这种重要的组织。新肌肉蛋白（MPS）的合成显着决定了肌肉是否会变得更大和强大，例如通过合成力生成力的肌原纤维（MyO）蛋白质来进行抵抗运动（REX），并/或通过能量实力（Endurance Storame（End））通过能量生产（MITOCHORDROCOCHIRAIL（MITOCOCHIAL）进行耐力（结束）。