Mechanisms of human skeletal muscle remodelling with exercise

运动重塑人体骨骼肌的机制

• 批准号: RGPIN-2015-04251
• 负责人: Moore, Daniel
• 金额: $ 2.11万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630597
• 关键词: Mechanisms; human; skeletal; muscle; remodelling

Skeletal muscle is an incredibly plastic tissue resulting from its remarkable ability to break down old and/or damaged proteins and make (synthesize) new functional ones. These processes occur simultaneously and continuously, are enhanced in response to exercise and nutrition, and ultimately function to ‘remodel’ this important tissue. The synthesis of new muscle proteins (MPS) significantly determines whether a muscle gets bigger and stronger, such as with resistance exercise (REX) through the synthesis of force-generating myofibrillar (MYO) proteins, and/or develop a greater endurance capacity, such as with endurance exercise (END) through the synthesis of energy-producing mitochondrial (MITO) proteins.

骨骼肌是一种令人难以置信的可塑性组织，它具有分解旧的和/或受损的蛋白质并合成(合成)新的功能蛋白质的非凡能力。这些过程同时且持续地发生，随着运动和营养的增加而增强，并最终起到‘重塑’这一重要组织的作用。新肌肉蛋白(MPS)的合成在很大程度上决定了肌肉是否变得更大、更强壮，例如通过合成产生力量的肌原纤维(MYO)蛋白质来进行阻力运动(REX)，和/或通过合成产生能量的线粒体(MITO)蛋白质来发展更强的耐力能力(例如耐力运动(END))。