Next generation of super resolution imaging techniques

从天文学到生物细胞分析，成像是研究我们环境的最基本和最基本的工具之一。虽然分辨率极限最初被认为是衍射极限（阿贝），但众所周知，亚衍射成像现在是可能的。然而，在实践中，超分辨率技术使用复杂的方法，能够在存在湍流、极化效应、不完美光学元件、斑点和衍射等现实世界条件下进行超分辨率样品，这些条件使它们受到限制。尽管各种理论和实验室技术的出现有所改善，但越来越需要实用且强大的模拟和优化工具来解决未来的超分辨率成像要求。提出的研究计划提出了一种创新的方法，将被开发和用于下一代超分辨率成像系统的显微镜领域。这一提案也为在加拿大发展新的专业知识和培养高素质的镜片设计人员提供了一个独特的机会。

Imaging is one of the most basic and fundamental tools to study our environment, from astronomy to biological cell analysis. While the resolution limit was originally considered as diffraction limit (Abbe), it is well known that sub-diffraction imaging is now possible. In practice, however, the super-resolution techniques use complex approaches to be able to super-resolved samples in the presence of real world condition such as turbulence, polarization effects, imperfect optical components, speckles, and diffraction which make them limited. Although the advent of various theoretical and laboratory techniques has improved, there is a growing need for a practical and robust simulation and optimisation tools to address future super-resolution imaging requirements. The proposed research program presents an innovative approach that will be developed and used in the field of microscopy for the next generation of super resolution imaging systems. This proposal also offers a unique opportunity to develop new expertise and train highly qualified personal in lens design in Canada.