Multimodal optical imaging investigation of neuronal, metabolic and vascular correlates of aging

衰老相关神经元、代谢和血管的多模态光学成像研究

• 批准号: 239876-2011
• 负责人: Lesage, Frederic
• 金额: $ 4.15万
• 依托单位: École Polytechnique de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=594250
• 关键词: Multimodal; optical; imaging; investigation; neuronal

Deteriorating cognitive function with aging has significant individual, social and economic consequences on the lives of Canadians, particularly given the current demographic context. The causes and mechanisms of cognitive decline remain unclear and could be manifold (neural, metabolic as well as vascular). There is evidence that healthy aging and disease have effects on baseline blood flow as well as vascular compliance, suggesting the relevance of hemodynamic measurements for investigating and eventually diagnosing age-related conditions.

随着年龄的增长，认知功能的恶化对加拿大人的生活产生了重大的个人、社会和经济后果，特别是在目前的人口背景下。认知能力下降的原因和机制尚不清楚，可能是多方面的（神经、代谢和血管）。有证据表明，健康的衰老和疾病对基线血流量和血管顺应性有影响，这表明血液动力学测量与调查和最终诊断与年龄相关的疾病有关。