Smart home-cage for combined optogenetics and electrophysiology

结合光遗传学和电生理学的智能家居笼

• 批准号: 493868-2016
• 负责人: Gosselin, Benoit
• 金额: $ 1.09万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Idea to Innovation
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=602902
• 关键词: Smart; home; cage; combined; optogenetics

We have previously developed the first fully wireless head mounted device to combine optical stimulation for optogenetics and electrophysiological recording within a single device. This system enables to activate and track brain activity in freely moving rodents in real time using a new microelectronic design and dedicated signal processing algorithms recently invented by Dr Gosselin at ULAVAL. This is the only tool to enable circuits' analysis in awake and behaving rodents, with high spatial resolution and at millisecond time scale, through large-scale electrophysiology technology combined with optogenetic capabilities, which is key for research. The researchers from all around the world need such a tool to advance knowledge of brain functions and to develop novel therapeutics against brain diseases.

我们之前已经开发了第一个完全无线的头戴式设备，将用于光遗传学和电生理记录的联合收割机光学刺激结合在单个设备中。该系统能够使用新的微电子设计和最近由ULAVAL的Gosselin博士发明的专用信号处理算法，在真实的时间内激活和跟踪自由移动的啮齿动物的大脑活动。这是唯一能够在清醒和行为啮齿动物中进行电路分析的工具，具有高空间分辨率和毫秒级时间尺度，通过大规模电生理学技术结合光遗传学能力，这是研究的关键。来自世界各地的研究人员需要这样一个工具来推进大脑功能的知识，并开发针对大脑疾病的新疗法。