Smart Material Transducers and Applications to In Vivo Microsystems
智能材料传感器及其在体内微系统中的应用
基本信息
- 批准号:RGPIN-2016-04252
- 负责人:
- 金额:$ 2.99万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2016
- 资助国家:加拿大
- 起止时间:2016-01-01 至 2017-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Microsystems with embedded sensors and actuators, or micro-electro-mechanical systems (MEMS), have developed increased functionalities that could allow the treatment and monitoring of lesions inside the body in a minimally invasive manner. However, significant barriers to their use in biological environment include their ineffective interaction with three dimensional (3D) tissues caused by their planar forms, fragility associated with their design complexity, and biocompatibility issues, leading to severely hindered performance or malfunctions of the devices. MEMS-based implants are still too large in many cases including vascular applications. Moreover, wireless operation is essential for implantable microsystems. Addressing these challenges require breakthrough approaches.
Toward bringing the medical potential of MEMS into reality, this research program will pursue novel paths that leverage non-traditional materials and processes to develop micro transducers and their packaged 3D microsystems in highly miniaturized, biocompatible, and robust/reliable forms. In particular, we will investigate how stimuli-responsive, smart materials, patterned in the micro/nano scales, could be an effective path to designing and constructing target in vivo transducers and devices. The benefit of this approach, brought by self-responsive designs, is that a device could be configured to simultaneously achieve 1) active/perceptive “smart” functionality enabled with embedded transducers, 2) ultimate miniaturization with extremely simplified design architectures, and 3) high robustness and reliability.
The short-term objective of this research is to study and develop miniaturized transducers realized via the use of smart materials and structures for biomedical and wireless implementations. Furthermore, in order to verify the effectiveness and practicality of these novel transducers, we will apply them to study and prototype innovative in vivo microsystems including drug-delivery smart stents and 3D-viewing microendoscopes that will advance targeted therapy and diagnosis of localized disease such as cardiovascular disease and cancers. To this end, this research will also investigate novel micro/nanofabrication processes that will serve as a key enabling technology for their production.
In the long term, we aim this research to offer ground-breaking technologies and products of intelligent microdevices that will shape the future of minimally invasive medicine and enable more effective healthcare delivery in Canada and worldwide. We also envision that the new findings and successful outcomes from this research will pioneer new applications in other areas beyond the particular scope in medical devices, while broadly contributing to further advances in microsystems, nanotechnology and applied physics.
具有嵌入式传感器和致动器的微系统,或微型机电系统(MEMS),已经开发出更多的功能,能够以微创的方式治疗和监测体内的病变。然而,它们在生物环境中应用的主要障碍包括平面形式导致它们与三维组织的相互作用不有效,与其设计复杂性相关的脆弱性,以及生物兼容性问题,导致设备的性能或故障严重受阻。基于MEMS的植入物在许多情况下仍然太大,包括血管应用。此外,无线操作对于植入式微系统是必不可少的。应对这些挑战需要突破性的方法。
为了将MEMS的医疗潜力变为现实,该研究计划将探索利用非传统材料和工艺的新途径,以高度小型化、生物兼容性和坚固/可靠的形式开发微型换能器及其封装的3D微系统。特别是,我们将研究在微/纳米尺度上构图的刺激响应型智能材料如何成为设计和构建体内靶向换能器和设备的有效途径。自响应设计带来的这种方法的好处是,设备可以配置为同时实现1)通过嵌入式换能器实现的有源/感知“智能”功能,2)极其简化的设计架构的终极小型化,以及3)高稳健性和可靠性。
这项研究的短期目标是研究和开发通过使用智能材料和结构实现的微型传感器,用于生物医学和无线实施。此外,为了验证这些新型换能器的有效性和实用性,我们将把它们应用于研究和制作创新的体内微系统,包括药物输送智能支架和3D观看显微内窥镜,这些系统将推进心血管疾病和癌症等局部疾病的靶向治疗和诊断。为此,这项研究还将研究新的微/纳米制造工艺,这些工艺将作为其生产的关键使能技术。
从长远来看,我们的目标是提供开创性的智能微设备技术和产品,这些技术和产品将塑造微创医学的未来,并使加拿大和世界各地能够更有效地提供医疗服务。我们还预计,这项研究的新发现和成功成果将在医疗设备特定范围以外的其他领域开创新的应用,同时广泛地为微系统、纳米技术和应用物理学的进一步发展做出贡献。
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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Takahata, Kenichi其他文献
Switch mode capacitive pressure sensors.
- DOI:
10.1038/s41378-022-00469-w - 发表时间:
2022 - 期刊:
- 影响因子:7.9
- 作者:
Shalabi, Nabil;Searles, Kyle;Takahata, Kenichi - 通讯作者:
Takahata, Kenichi
Micromachined antenna stents and cuffs for monitoring intraluminal pressure and flow
- DOI:
10.1109/jmems.2006.880229 - 发表时间:
2006-10-01 - 期刊:
- 影响因子:2.7
- 作者:
Takahata, Kenichi;Gianchandani, Yogesh B.;Wise, Kensall D. - 通讯作者:
Wise, Kensall D.
Intelligent Ureteral Stent for Early Detection of Hydronephrosis
- DOI:
10.1002/admt.202100652 - 发表时间:
2021-08-27 - 期刊:
- 影响因子:6.8
- 作者:
Darestani, Mohammad Reza Yousefi;Shalabi, Nabil;Takahata, Kenichi - 通讯作者:
Takahata, Kenichi
Transforming carbon nanotube forest from darkest absorber to reflective mirror
- DOI:
10.1063/1.4744429 - 发表时间:
2012-08-06 - 期刊:
- 影响因子:4
- 作者:
Saleh, Tanveer;Moghaddam, Mehran Vandani;Takahata, Kenichi - 通讯作者:
Takahata, Kenichi
A resonant-heating stent for wireless endohyperthermia treatment of restenosis
- DOI:
10.1016/j.sna.2015.10.046 - 发表时间:
2015-12-01 - 期刊:
- 影响因子:4.6
- 作者:
Luo, Yi;Dahmardeh, Masoud;Takahata, Kenichi - 通讯作者:
Takahata, Kenichi
Takahata, Kenichi的其他文献
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{{ truncateString('Takahata, Kenichi', 18)}}的其他基金
Medical Microsystems and Enabling Technologies for Precision Medicine
精准医疗的医疗微系统和支持技术
- 批准号:
RGPIN-2022-04924 - 财政年份:2022
- 资助金额:
$ 2.99万 - 项目类别:
Discovery Grants Program - Individual
Smart Material Transducers and Applications to In Vivo Microsystems
智能材料传感器及其在体内微系统中的应用
- 批准号:
RGPIN-2016-04252 - 财政年份:2021
- 资助金额:
$ 2.99万 - 项目类别:
Discovery Grants Program - Individual
Side-viewing endoscopic catheter with distal micro rotary scanner for minimally invasive high-resolution intraluminal imaging - Phase I
带有远端微型旋转扫描仪的侧视内窥镜导管,用于微创高分辨率管腔内成像 - 第一阶段
- 批准号:
556130-2020 - 财政年份:2020
- 资助金额:
$ 2.99万 - 项目类别:
Idea to Innovation
Smart Material Transducers and Applications to In Vivo Microsystems
智能材料传感器及其在体内微系统中的应用
- 批准号:
RGPIN-2016-04252 - 财政年份:2020
- 资助金额:
$ 2.99万 - 项目类别:
Discovery Grants Program - Individual
Intelligent Ureteral Stent System for Prevention of Renal Damage
预防肾损伤的智能输尿管支架系统
- 批准号:
523795-2018 - 财政年份:2019
- 资助金额:
$ 2.99万 - 项目类别:
Collaborative Health Research Projects
Smart Material Transducers and Applications to In Vivo Microsystems
智能材料传感器及其在体内微系统中的应用
- 批准号:
RGPIN-2016-04252 - 财政年份:2019
- 资助金额:
$ 2.99万 - 项目类别:
Discovery Grants Program - Individual
Intelligent Ureteral Stent System for Prevention of Renal Damage
预防肾损伤的智能输尿管支架系统
- 批准号:
523795-2018 - 财政年份:2018
- 资助金额:
$ 2.99万 - 项目类别:
Collaborative Health Research Projects
Smart Material Transducers and Applications to In Vivo Microsystems
智能材料传感器及其在体内微系统中的应用
- 批准号:
RGPIN-2016-04252 - 财政年份:2018
- 资助金额:
$ 2.99万 - 项目类别:
Discovery Grants Program - Individual
Smart Material Transducers and Applications to In Vivo Microsystems
智能材料传感器及其在体内微系统中的应用
- 批准号:
RGPIN-2016-04252 - 财政年份:2017
- 资助金额:
$ 2.99万 - 项目类别:
Discovery Grants Program - Individual
Canada Research Chair in Advanced Micro/Nanofabrication and MEMS
加拿大先进微/纳米制造和 MEMS 研究主席
- 批准号:
1000228268-2012 - 财政年份:2017
- 资助金额:
$ 2.99万 - 项目类别:
Canada Research Chairs
相似海外基金
Smart Material Transducers and Applications to In Vivo Microsystems
智能材料传感器及其在体内微系统中的应用
- 批准号:
RGPIN-2016-04252 - 财政年份:2021
- 资助金额:
$ 2.99万 - 项目类别:
Discovery Grants Program - Individual
Smart Material Transducers and Applications to In Vivo Microsystems
智能材料传感器及其在体内微系统中的应用
- 批准号:
RGPIN-2016-04252 - 财政年份:2020
- 资助金额:
$ 2.99万 - 项目类别:
Discovery Grants Program - Individual
Smart Material Transducers and Applications to In Vivo Microsystems
智能材料传感器及其在体内微系统中的应用
- 批准号:
RGPIN-2016-04252 - 财政年份:2019
- 资助金额:
$ 2.99万 - 项目类别:
Discovery Grants Program - Individual
Smart Material Transducers and Applications to In Vivo Microsystems
智能材料传感器及其在体内微系统中的应用
- 批准号:
RGPIN-2016-04252 - 财政年份:2018
- 资助金额:
$ 2.99万 - 项目类别:
Discovery Grants Program - Individual
Smart Material Transducers and Applications to In Vivo Microsystems
智能材料传感器及其在体内微系统中的应用
- 批准号:
RGPIN-2016-04252 - 财政年份:2017
- 资助金额:
$ 2.99万 - 项目类别:
Discovery Grants Program - Individual
CAREER: Elucidating the material properties of complex tunable biopolymer networks using single-molecule nano stress-strain transducers and sensors
职业:使用单分子纳米应力应变传感器和传感器阐明复杂可调谐生物聚合物网络的材料特性
- 批准号:
1255446 - 财政年份:2013
- 资助金额:
$ 2.99万 - 项目类别:
Continuing Grant
SBIR Phase I:A New High-Strain Material for Medical Ultrasound Transducers
SBIR第一期:用于医用超声换能器的新型高应变材料
- 批准号:
0339430 - 财政年份:2004
- 资助金额:
$ 2.99万 - 项目类别:
Standard Grant
Development of high temperature ultrasonic transducers for industrial material process monitoring
开发用于工业材料过程监测的高温超声波传感器
- 批准号:
192858-1996 - 财政年份:1998
- 资助金额:
$ 2.99万 - 项目类别:
Strategic Projects - Group
Development of high temperature ultrasonic transducers for industrial material process monitoring
开发用于工业材料过程监测的高温超声波传感器
- 批准号:
192858-1996 - 财政年份:1997
- 资助金额:
$ 2.99万 - 项目类别:
Strategic Projects - Group
Development of high temperature ultrasonic transducers for industrial material process monitoring
开发用于工业材料过程监测的高温超声波传感器
- 批准号:
192858-1996 - 财政年份:1996
- 资助金额:
$ 2.99万 - 项目类别:
Strategic Projects - Group