Democratizing nanopore-based research to enable novel diagnostics

使基于纳米孔的研究大众化以实现新型诊断

• 批准号: 493939-2016
• 负责人: TabardCossa, Vincent
• 金额: $ 19.71万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Idea to Innovation
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=618330
• 关键词: Democratizing; nanopore; based; research; enable

This project will further develop the University of Ottawa's novel nanopore fabrication technology from the current lab research prototype, to a robust device that can be delivered to third parties for use in their research. It is a key step in our long-term goal to develop a novel molecular detection platform for in-vitro medical diagnostics market with our commercial partner, Abbott Laboratories. Medicine is undergoing a technological revolution, whereby critical healthcare decisions will be driven by a patient's unique molecular profile. This emerging era of personalized medicine is being made possible by new technologies that are sensitive enough to investigate fundamental biological building blocks like DNA, RNA, and proteins, one molecule at a time. As these technologies mature, they will impact all aspects of medicine: companion diagnostics will determine whether or not a cancer patient will respond to a new targeted therapy, a simple blood test will determine whether a concussion requires further treatment, and critical care physicians will test a patient's heart health at the bedside instead of waiting hours for results from a centralized lab. Solid-state nanopores - nanometer sized holes in silicon membranes - are a leading candidate technology driving this revolution, but there is currently no appropriate fabrication techniques that provide a viable path to commercialize solid-state nanopore-based technologies. Our revolutionary pore fabrication method, controlled dielectric breakdown, or CBD, solves this issue in a simple, scalable, low-cost way. The goal of this project is to develop CBD into a prototype bench-top nanopore fabrication and sensing instrument that is simple and robust enough to be used by health-focused researchers to develop a new generation of improved diagnostics. Ultimately this project will improve Canadian healthcare and help Canada strengthen its position as a global leader in the development of new health and nanotechnologies.

该项目将进一步开发渥太华大学的新型纳米孔制造技术，从目前的实验室研究原型，到一个强大的设备，可以交付给第三方用于他们的研究。这是我们长期目标的关键一步，即与我们的商业合作伙伴雅培实验室合作，为体外医学诊断市场开发一种新型分子检测平台。医学正在经历一场技术革命，关键的医疗保健决策将由患者独特的分子特征驱动。这个新兴的个性化医疗时代正在通过新技术成为可能，这些技术足够敏感，可以一次一个分子地研究基本的生物构建模块，如DNA，RNA和蛋白质。随着这些技术的成熟，它们将影响医学的各个方面：伴随诊断将确定癌症患者是否会对新的靶向治疗产生反应，简单的血液测试将确定脑震荡是否需要进一步治疗，重症监护医生将在床边测试患者的心脏健康，而不是等待几个小时的集中实验室结果。固态纳米孔-硅膜中的纳米尺寸的孔-是推动这场革命的领先候选技术，但目前没有合适的制造技术提供将基于固态纳米孔的技术商业化的可行途径。我们革命性的孔制造方法，受控介电击穿，或CBD，以简单，可扩展，低成本的方式解决了这个问题。该项目的目标是将CBD开发成一种原型台式纳米孔制造和传感仪器，该仪器简单而强大，足以供以健康为重点的研究人员用于开发新一代改进的诊断方法。最终，该项目将改善加拿大的医疗保健，并帮助加拿大加强其作为新健康和纳米技术发展的全球领导者的地位。