Solid-state nanopores: tools for single-molecule biophysics

固态纳米孔：单分子生物物理学工具

• 批准号: 402168-2011
• 负责人: TabardCossa, Vincent
• 金额: $ 1.46万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=573182
• 关键词: Solid; state; nanopores; tools; single

This research program is dedicated to the development of novel techniques and methods to manipulate and characterize single-molecules using nanoscale devices, to unravel the basic physics governing the behaviour of biological molecules in nanoconfined geometries, and to translate these discoveries into new tools for the life sciences. While this research program is driven by the exploration of unique detection and actuation modalities, the manipulation and characterization of individual molecules within nanoscale fluidic environments (i) represents an important and largely uncharted regime in which interesting new physics can dominate and (ii) enables new quantitative measurements, with exceptional sensitivity and speed, on the structure and behavior of biological molecules. As such this program will provide HQP with strong, multidisciplinary training in a broad range of techniques and concepts from physics to molecular biology. This research program will offer a unique opportunity for HQP to acquire valuable technical and scientific skills facilitating their transition to tomorrow's research and technology development environments in the fields of biophysics and biotechnologies.

该研究计划致力于开发新的技术和方法，以操纵和表征单分子使用纳米级设备，以解开基本物理控制生物分子的行为在nanobinited几何形状，并将这些发现转化为生命科学的新工具。虽然这项研究计划是由独特的检测和驱动模式的探索驱动的，但纳米级流体环境中单个分子的操纵和表征（i）代表了一个重要的且在很大程度上未知的制度，其中有趣的新物理学可以占主导地位，并且（ii）能够以异常的灵敏度和速度对生物分子的结构和行为进行新的定量测量。因此，该计划将为HQP提供从物理学到分子生物学的广泛技术和概念的强有力的多学科培训。这项研究计划将为HQP提供一个独特的机会，以获得宝贵的技术和科学技能，促进他们过渡到未来的研究和技术开发环境中的生物物理学和生物技术领域。