Evolution and diversity of synaptic transmission: Roles for voltage-gated calcium channels and PDZ-domain mediated scaffolding

突触传递的进化和多样性：电压门控钙通道和 PDZ 域介导的支架的作用

• 批准号: RGPIN-2016-06023
• 负责人: Senatore, Adriano
• 金额: $ 2.26万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629595
• 关键词: Evolution; diversity; synaptic; transmission; Roles

Synaptic transmission lies at the very core of nervous system function. In my research, I seek to understand how synaptic structure and function differs between distantly-related animals, and how the synapse evolved. Indeed, gaining a deep, phylogenetic understanding of the synapse and its evolution will help broaden our understanding of this complex and dynamic cell-cell signaling apparatus, basic science that can help guide future efforts to treat diseases of the nervous system involving deficiencies in synaptic transmission.

突触传递是神经系统功能的核心。在我的研究中，我试图了解远亲动物之间突触结构和功能的不同，以及突触是如何进化的。事实上，深入了解突触及其进化的系统发生学将有助于拓宽我们对这种复杂而动态的细胞-细胞信号装置的理解，这是一门基础科学，可以帮助指导未来治疗涉及突触传递缺陷的神经系统疾病的努力。