Eyes over ears? Bats as neuroethological models for understanding visual capture

眼睛盖过耳朵？

• 批准号: RGPIN-2014-04872
• 负责人: Ratcliffe, John
• 金额: $ 3.64万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=631966
• 关键词: Eyes; over; ears; Bats; neuroethological

How we perceive the world depends on the environmental information available to our senses and our brain’s ability to integrate the resulting neural information into a unified experience. My long-term objective is better understand how animals - vertebrates and invertebrates alike - use sensory information to construct internal representations of their often changing external environments. Over the course of this 5-year research grant, I will use bats to investigate how they and other vertebrates, including ourselves, combine visual and auditory information to build representations of the spatial arrangements of objects in our surroundings. Such representations are important for orientation and object recognition and are used to make decisions about what to eat, what to avoid, who to court, and how to get home. Among the senses, vision and hearing have most in common and the greatest potential for similarity in the way the brain represents the information gathered through them. For this same reason, if visual and auditory information are contradictory there is potential for confusion, especially if the brain cannot quickly decide which is the more accurate and reliable source. For many birds and mammals, when auditory and visual information do not agree, the brain often chooses visual over auditory information to localize objects. Several explanations, none mutually exclusive, have been suggested to account for this. One is historical – because vision precedes hearing in the evolution of vertebrates, vision has had a greater impact on the evolution of hearing than hearing has had on vision. A second is developmental – suggesting that as the brain develops the visual system has a disproportionate influence on how the auditory system builds images of the outside world. A third postulates that the brain makes real-time estimations on the relative value of available visual and auditory information. This last explanation implies that visual dominance largely results because for much of the time for many animals visible light is more reliable than audible sound. Testing these different hypotheses using bats as subjects is the focus of my research proposal. Bats have evolved to operate under the cover of night. The majority of today’s species, through extraordinary adaptations to their auditory and vocal systems, are able to ‘see’ with their ears. As a result of laryngeal echolocation, bats can do things that non-echolocating animals cannot do using sound: based on the echoes from their calls they can accurately determine an object’s distance and also its size, shape, and texture. Bats are not blind, but because many species rely more on echoes than light for orientation, bats provide an excellent opportunity to study how the mammalian brain builds visual and auditory images and how evolution, development, and current environmental conditions each impact how mammals, faced with conflicting information, decide which sense to rely on. Evolution, development, and current conditions must all exert an influence on how vertebrates prioritize and integrate audio-visual information. I will conduct behavioural, comparative, and neuroanatomical studies to disentangle their roles. I have also designed experiments to see if some bats are capable of cross-modal recognition. That is do bats perceive through echolocation images similar to those perceived through vision? In meeting these short-term objectives, my research will add to our understanding of how animals build coherent internal representations of the world around them. Ultimately, the results may help us to better comprehend aspects of the autism spectrum and schizophrenia, disorders associated with difficulties in integrating sensory information.

我们如何感知世界取决于我们感官所能获得的环境信息以及我们的大脑将由此产生的神经信息整合成统一体验的能力。我的长期目标是更好地了解动物（脊椎动物和无脊椎动物）如何使用感官信息来构建经常变化的外部环境的内部表征。在这项为期 5 年的研究资助过程中，我将利用蝙蝠来研究它们和其他脊椎动物（包括我们人类）如何结合视觉和听觉信息来构建我们周围物体的空间排列的表征。这种表征对于定向和物体识别非常重要，并用于决定吃什么、避免吃什么、向谁求爱以及如何回家。在各种感官中，视觉和听觉在大脑表示通过它们收集的信息的方式方面最有共同点，也最有可能相似。出于同样的原因，如果视觉和听觉信息相互矛盾，则可能会产生混乱，特别是如果大脑无法快速确定哪个是更准确和可靠的来源。对于许多鸟类和哺乳动物来说，当听觉和视觉信息不一致时，大脑通常会选择视觉信息而不是听觉信息来定位物体。有人提出了几种相互排斥的解释来解释这一点。一个是历史性的——因为在脊椎动物的进化中视觉先于听觉，视觉对听觉进化的影响比听觉对视觉的影响更大。第二个是发育性的——表明随着大脑的发育，视觉系统对听觉系统如何构建外部世界的图像有着不成比例的影响。第三种假设是大脑对可用视觉和听觉信息的相对价值进行实时估计。最后的解释意味着视觉优势很大程度上是由于许多动物在大部分时间可见光比可听声音更可靠而产生的。使用蝙蝠作为受试者来测试这些不同的假设是我的研究计划的重点。蝙蝠已经进化到可以在夜晚的掩护下活动。当今的大多数物种，通过对听觉和发声系统的非凡适应，能够用耳朵“看到”。由于喉部回声定位，蝙蝠可以做到非回声定位动物无法利用声音做到的事情：根据叫声的回声，它们可以准确地确定物体的距离及其大小、形状和纹理。蝙蝠不是盲目的，但由于许多物种更多地依赖回声而不是光来定位，因此蝙蝠提供了一个绝佳的机会来研究哺乳动物的大脑如何构建视觉和听觉图像，以及进化、发育和当前的环境条件如何影响哺乳动物在面对相互矛盾的信息时如何决定依靠哪种感觉。进化、发展和现状都必须对脊椎动物如何优先考虑和整合视听信息产生影响。我将进行行为、比较和神经解剖学研究来理清他们的角色。我还设计了实验来看看某些蝙蝠是否能够进行跨模式识别。也就是说，蝙蝠通过回声定位图像进行感知的方式与通过视觉感知的方式类似吗？在实现这些短期目标的过程中，我的研究将加深我们对动物如何构建对周围世界连贯的内部表征的理解。最终，这些结果可能有助于我们更好地理解自闭症谱系和精神分裂症的各个方面，这些疾病与感觉信息整合困难相关。