Development of a confocal endoscope for gastrointestinal cancer diagnosis

近年来，各种光学显微镜技术已经发展用于生物组织的非破坏性成像，包括光学相干断层扫描，反射模式共聚焦显微镜，荧光模式共聚焦显微镜和多光子激发显微镜。每种成像方式都有其自身的优点和缺点。**以前，共聚焦显微镜已经在皮肤癌成像方面取得了进展，并在其他癌症诊断中表现出潜力。然而，将共焦成像 ** 模式移动到内窥镜应用中具有挑战性，因为必须开发小型化导管探头 ** 以穿过尺寸为几毫米直径的内窥镜器械通道。在这项研究中，我们的目标是使用MEMES（微机电 ** 系统）技术，使一个微型共焦光学探头，将产生组织学 ** 横截面图像和三维图像的组织在体内的胃肠道（胃肠道）癌症 ** 诊断。

In recent years, various optical microscopy techniques have been developed for nondestructive**imaging of biological tissues, including optical coherence tomography, reflectancemode**confocal microscopy, fluorescence-mode confocal microscopy, and multiphoton**excitation microscopy. Each imaging modality has its own advantages and disadvantages.**Previously, confocal microscopy has shown progress in skin cancer imaging and**demonstrated potential in other cancer diagnosis. However, moving confocal imaging**modalities into endoscopy applications is challenging in that miniaturized catheter probes**have to be developed to pass through the endoscope instrument channel that is a few**millimeter diameter in size. In this research, we aim to use MEMES (Microelectromechanical**Systems) technology to make a miniature confocal optical probe that will produce histologylike**cross sectional images and 3D images of tissue in vivo for GI (gastrointestinal) cancer**diagnosis.