Development of a confocal endoscope for gastrointestinal cancer diagnosis

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In recent years, various optical microscopy techniques have been developed for nondestructive**imaging of biological tissues, including optical coherence tomography, reflectancemode**confocal microscopy, fluorescence-mode confocal microscopy, and multiphoton**excitation microscopy. Each imaging modality has its own advantages and disadvantages.**Previously, confocal microscopy has shown progress in skin cancer imaging and**demonstrated potential in other cancer diagnosis. However, moving confocal imaging**modalities into endoscopy applications is challenging in that miniaturized catheter probes**have to be developed to pass through the endoscope instrument channel that is a few**millimeter diameter in size. In this research, we aim to use MEMES (Microelectromechanical**Systems) technology to make a miniature confocal optical probe that will produce histologylike**cross sectional images and 3D images of tissue in vivo for GI (gastrointestinal) cancer**diagnosis.