Development of a confocal endoscope for gastrointestinal cancer diagnosis

开发用于胃肠道癌症诊断的共焦内窥镜

• 批准号: 508410-2017
• 负责人: Chiao, Mu
• 金额: $ 14.8万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=647528
• 关键词: Development; confocal; endoscope; gastrointestinal; cancer

In recent years, various optical microscopy techniques have been developed for nondestructive**imaging of biological tissues, including optical coherence tomography, reflectancemode**confocal microscopy, fluorescence-mode confocal microscopy, and multiphoton**excitation microscopy. Each imaging modality has its own advantages and disadvantages.**Previously, confocal microscopy has shown progress in skin cancer imaging and**demonstrated potential in other cancer diagnosis. However, moving confocal imaging**modalities into endoscopy applications is challenging in that miniaturized catheter probes**have to be developed to pass through the endoscope instrument channel that is a few**millimeter diameter in size. In this research, we aim to use MEMES (Microelectromechanical**Systems) technology to make a miniature confocal optical probe that will produce histologylike**cross sectional images and 3D images of tissue in vivo for GI (gastrointestinal) cancer**diagnosis.

近年来，各种光学显微镜技术被发展用于生物组织的无损成像，包括光学相干断层扫描、反射模式共聚焦显微镜、荧光模式共聚焦显微镜和多光子激发显微镜。每种成像方式都有自己的优点和缺点。**此前，共聚焦显微镜在皮肤癌成像方面取得了进展，并在其他癌症诊断方面显示出潜力。然而，将共聚焦成像模式移动到内窥镜应用中是具有挑战性的，因为必须开发小型化的导管探针**，以通过内窥镜仪器通道，其直径只有几毫米。在这项研究中，我们的目标是利用MEMES（微机电系统）技术制作一种微型共聚焦光学探针，该探针可以产生组织样的横截面图像和体内组织的三维图像，用于GI（胃肠道）癌症的诊断。