Multimodal sensor arrays for high throughput biological analysis

用于高通量生物分析的多模态传感器阵列

• 批准号: 523782-2018
• 负责人: GhafarZadeh, Ebrahim
• 金额: $ 1.82万
• 依托单位: York University
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=651750
• 关键词: Multimodal; sensor; arrays; throughput; biological

Recent advances in hybrid microfluidic/microelectronic technologies have enabled the development of**High-Throughput Screening techniques for various applications including drug discovery. Among various**competing standard integrated circuit (IC) technologies, Complementary Metal Oxide Semiconductor, by**offering a distinct cost, integrated sensors and circuits, is the best candidate. This technology has been widely**used in a variety of applications such as communications, computer and other consumer electronic applications,**but very recently it has attracted the attention for the development of ICs for life science applications such as**DNA sequencing and cellular analysis.**Despite great advances, hybrid CMOS microfluidics systems still suffers limitations in their reusability and**biocompatibility. This collaboration research between York University and its industrial partner - Medella**Health will aim to address this challenge and offer a CMOS compatible solution. The company has made**significant advancements in improving the nanomaterial required for transducing the biosensor signal. The**short term goal of this project is to offer a solution to enhance the biocompatibility of CMOS by coating the**metal nanoparticles developed by company. The long-term goal for the industry partner is to develop a new**technology for measuring cellular activities, which can be used for many applications, including cell-based**drug tests for cancer.

混合微流体/微电子技术的最新进展使得高通量筛选技术的发展成为可能，用于包括药物发现在内的各种应用。在各种竞争的标准集成电路（IC）技术中，互补金属氧化物半导体由于提供独特的成本、集成传感器和电路而成为最佳候选者。该技术已被广泛 ** 用于各种应用，如通信、计算机和其他消费电子应用 **，但最近，它吸引了人们对生命科学应用IC开发的关注，如 **DNA测序和细胞分析。尽管有很大的进步，混合CMOS微流体系统仍然受到其可重复使用性和 ** 生物相容性的限制。约克大学与其工业合作伙伴Medella**Health之间的这项合作研究旨在应对这一挑战，并提供CMOS兼容的解决方案。该公司在改善生物传感器信号转换所需的纳米材料方面取得了重大进展。本项目的短期目标是提供一种解决方案，通过涂覆公司开发的金属纳米颗粒来增强CMOS的生物相容性。该行业合作伙伴的长期目标是开发一种测量细胞活性的新技术，该技术可用于许多应用，包括基于细胞的癌症药物测试。