Multimodal sensor arrays for high throughput biological analysis

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Recent advances in hybrid microfluidic/microelectronic technologies have enabled the development of**High-Throughput Screening techniques for various applications including drug discovery. Among various**competing standard integrated circuit (IC) technologies, Complementary Metal Oxide Semiconductor, by**offering a distinct cost, integrated sensors and circuits, is the best candidate. This technology has been widely**used in a variety of applications such as communications, computer and other consumer electronic applications,**but very recently it has attracted the attention for the development of ICs for life science applications such as**DNA sequencing and cellular analysis.**Despite great advances, hybrid CMOS microfluidics systems still suffers limitations in their reusability and**biocompatibility. This collaboration research between York University and its industrial partner - Medella**Health will aim to address this challenge and offer a CMOS compatible solution. The company has made**significant advancements in improving the nanomaterial required for transducing the biosensor signal. The**short term goal of this project is to offer a solution to enhance the biocompatibility of CMOS by coating the**metal nanoparticles developed by company. The long-term goal for the industry partner is to develop a new**technology for measuring cellular activities, which can be used for many applications, including cell-based**drug tests for cancer.