Mapping interactions between Phytoglycogen and bioactive compounds for biotechnological**applications

绘制植物糖原和生物活性化合物之间的相互作用以用于生物技术**应用

• 批准号: 523519-2018
• 负责人: Ladizhansky, Vladimir
• 金额: $ 1.8万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=656320
• 关键词: Mapping; interactions; between; Phytoglycogen; bioactive

Mirexus Biotechnologies Inc. is an emerging Canadian company specializing in the development of novel**natural biomaterials for applications in personal care, nutrition and biomedicine. The company's proprietary**biomaterial phytoglycogen, a natural polysaccharide extracted from sweet corn, is produced as monodisperse,**biodegradable and non-toxic nanoparticle, and is safe for human use.**Due to its excellent biocompatibility and the principal capability to encapsulate small molecules,**phytoglycogen is considered an attractive platform for the development of novel delivery systems for**nutraceutically, cosmetically and pharmacologically active compounds which are poorly soluble, or cannot**transverse cell membranes on their own.**Fundamental understanding of the features of phytoglycogen that allow it to bind and carry other molecules is**essential for the development of efficient delivery systems. To assist Mirexus with the development of new**generation of products, a research team led by Professor Vladimir Ladizhansky proposes to use a method of**Nuclear Magnetic Resonance and design special screening tests that would be able to quickly determine how**strongly the target molecules interact with phytoglycogen, and further identify molecular and structural motifs**that promote interactions with phytoglycogen.**The knowledge and methodologies designed in this project would be an essential step in creating new**products. It would allow the company to focus on the development of new specific active compounds that are**more likely to interact with phytoglycogen, or to develop phytoglycogen derivatives which can interact with a**wider spectrum of bioactive compounds. Mirexus is currently building a new manufacturing facility in Guelph;**in additional to obvious benefits to health and well-being, the development of new products would help create**new jobs in both R&D and production.

Mirexus Biotechnologies Inc.是一家新兴的加拿大公司，专门开发用于个人护理，营养和生物医学的新型天然生物材料。该公司专有的 ** 生物材料植物糖原是一种从甜玉米中提取的天然多糖，以单分散，** 可生物降解和无毒的纳米颗粒形式生产，对人类使用安全。由于其优异的生物相容性和包封小分子的主要能力，** 植物糖原被认为是开发新型递送系统的有吸引力的平台，用于开发溶解性差或自身不能 ** 穿过细胞膜的 ** 营养品，化妆品和药物活性化合物。对植物糖原结合和携带其他分子的特性的基本理解对于开发有效的递送系统是至关重要的。为了帮助Mirexus开发新一代产品，由弗拉基米尔拉迪赞斯基教授领导的研究小组提出使用核磁共振方法并设计特殊的筛选测试，能够快速确定目标分子与植物糖原相互作用的强度，并进一步确定促进与植物糖原相互作用的分子和结构基序。本项目中设计的知识和方法将是创造新 ** 产品的重要步骤。这将使该公司能够专注于开发新的特定活性化合物，这些化合物更有可能与植物糖原相互作用，或者开发可以与更广泛的生物活性化合物相互作用的植物糖原衍生物。Mirexus目前正在圭尔夫建设一个新的制造工厂;** 除了对健康和福祉的明显好处外，新产品的开发将有助于在研发和生产方面创造 ** 新的就业机会。