Mapping interactions between Phytoglycogen and active compounds for biomedical applications

绘制植物糖原和活性化合物之间的相互作用以用于生物医学应用

• 批准号: 538817-2019
• 负责人: Ladizhansky, Vladimir
• 金额: $ 0.88万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Engage Plus Grants Program
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=674808
• 关键词: Mapping; interactions; between; Phytoglycogen; active

Mirexus Biotechnologies Inc. is an emerging Canadian company that has developed a novel biomaterialextracted from corn, called phytoglycogen. This all-natural biomaterial has unique properties that enable it tooutperform human-made (i.e, synthetic) molecules that are currently used in pharmaceuticals, and skin care andnatural health products. Specifically, phytoglycogen is non-toxic, can interact with and envelop other smallmolecules, and can enter into our cells; therefore, it can be used as a safe "delivery system." For example, it canbe used to shuttle medications into cells that they would not have otherwise been able to enter. However,before phytoglycogen can be used for this purpose, more needs to be known about how it interacts with othersmall molecules.A research team led by Physics Professor Dr. Vladimir Ladizhansky proposes to design a new set of screeningtests that take advantage of the advanced molecular imaging techniques (i.e., Nuclear Magnetic Resonance)available at the University of Guelph. They aim to use these tests to quickly and accurately find out howstrongly phytoglycogen interacts with molecules of interest, and to determine the specific structural propertiesthat enable other molecules to interact with phytoglycogen in the desired ways.The novel methods designed in this project, and the knowledge that they will enable, are essential; theyrepresent the critical first step that must be completed before new phytoglycogen-based products can bedeveloped. The knowledge gained will enable Mirexus Biotechnologies Inc. to focus product development onthe molecules that are most likely to interact with phytoglycogen. It will also enable them to design newversions of phytoglycogen that can interact with a wider spectrum of bioactive molecules. Ultimately, theproposed research will enable Mirexus Biotechnologies Inc. to develop new products, enter new markets,increase revenue, and create new jobs in research and development, as well as manufacturing and sales-allwhile providing safer and more effective beauty and healthcare products for Canadians.

Mirexus Biotechnologies Inc.是一家新兴的加拿大公司，开发了一种从玉米中提取的新型生物材料，称为植物糖原。这种全天然的生物材料具有独特的性能，使其能够超越目前用于制药、护肤和天然健康产品的人造（即合成）分子。具体而言，植物糖原是无毒的，可以与其他小分子相互作用并包裹其他小分子，并且可以进入我们的细胞;因此，它可以用作安全的“递送系统”。“例如，它可以用来将药物运送到细胞中，否则它们将无法进入。然而，在植物糖原可以用于这一目的之前，需要更多地了解它如何与其他小分子相互作用。由物理学教授弗拉基米尔拉迪赞斯基博士领导的一个研究小组提出设计一套新的筛选测试，利用先进的分子成像技术（即，核磁共振），可在圭尔夫大学获得。他们的目标是利用这些测试来快速准确地找出植物糖原与感兴趣的分子相互作用的强度，并确定使其他分子能够以所需方式与植物糖原相互作用的特定结构特性。它们代表了在开发新的基于植物糖原的产品之前必须完成的关键的第一步。所获得的知识将使Mirexus Biotechnologies Inc. to focus焦点product产品development开发onthe molecules分子that are most最likely最有可能to interact相互作用with phytoglycogen植物糖原.这也将使他们能够设计新版本的植物糖原，可以与更广泛的生物活性分子相互作用。最终，拟议的研究将使Mirexus生物技术公司。开发新产品，进入新市场，增加收入，在研发、制造和销售方面创造新的就业机会，同时为加拿大人提供更安全、更有效的美容和保健产品。