Supramolecular-based Fluorescent Sensors and Surfactants

超分子荧光传感器和表面活性剂

• 批准号: RGPIN-2016-04905
• 负责人: Wagner, Brian
• 金额: $ 1.82万
• 依托单位: University of Prince Edward Island
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=709522
• 关键词: Supramolecular; based; Fluorescent; Sensors; Surfactants

Supramolecular chemistry, or "chemistry beyond the molecule", involves structures consisting of two or more molecules held together by weak forces of attraction as opposed to chemical bonds. A simple example of a supramolecular system is a host-guest inclusion complex, in which a guest molecule becomes included within the cavity of a larger, cage-like organic host molecule (like a ball in a bucket). The most common family of host molecules are the cyclodextrins (CDs), cyclic forms of glucose sugar that take on a bucket-like shape in water, and strongly bind guest molecules inside their internal cavities. Building upon the previous success in my research group involving fluorescence-based investigations of the fundamental properties of host-guest inclusion systems, the transformative research to be supported by this proposal involves the novel application of such supramolecular systems in two important areas: 1) molecular sensing and 2) supramolecular surfactants and micelles for molecular delivery. Molecular sensing involves the detection and measurement of specific target molecules, such as organic environmental pollutants; three such projects are proposed. First, the rational design of chemically modified CDs will be undertaken to obtain hosts with targeted binding properties, to serve as sensors for specific guests of interest. Second, the potential for fluorescent signal enhancement in non-aqueous solutions will be explored, to extend the use of supramolecular-based sensors beyond water solutions. This part of the study will include fundamental investigations into the currently understudied phenomena of host-guest inclusion occurring in non-aqueous media. Third, the potential application of two fluorescent, uniquely-shaped hosts as fluorescent sensors will be explored. In molecular delivery, a specific molecule of interest, such as a drug, is encapsulated or attached to a molecular system, transported to the area of interest, such as a tumor, and released to act upon the target area. A specific molecular delivery project is proposed, involving the design and synthesis of supramolecular host-guest surfactants, which can form micelles or vesicles, large cell-like molecular structures which can incorporate drug molecules, and which can be triggered to disrupt to release the drug at a target site. Thus this project involves a balanced combination of fundamental and targeted, applied research.

超分子化学，或“超越分子的化学”，涉及由两个或多个分子通过弱吸引力而不是化学键结合在一起组成的结构。超分子体系的一个简单例子是主客体包合复合物，其中客体分子被包含在更大的笼状有机主体分子的空腔内（就像桶中的球）。最常见的宿主分子家族是环糊精（CD），葡萄糖的环状形式，在水中呈桶状，并在其内部空腔内强烈结合客体分子。在我的研究小组先前成功的基础上，涉及对主客体包合体系基本性质的基于荧光的研究，该提案支持的变革性研究涉及这种超分子体系在两个重要领域的新应用：1）分子传感和2）用于分子传递的超分子表面活性剂和胶束。分子传感涉及检测和测量特定的目标分子，如有机环境污染物;提出了三个这样的项目。首先，将进行化学修饰的CD的合理设计，以获得具有目标结合特性的宿主，作为感兴趣的特定客人的传感器。第二，在非水溶液中的荧光信号增强的潜力将被探索，以扩大使用超分子为基础的传感器超越水溶液。这部分的研究将包括对目前未充分研究的非水介质中发生的主客体包含现象的基本调查。第三，将探索两种荧光的、形状相似的宿主作为荧光传感器的潜在应用。在分子递送中，感兴趣的特定分子（例如药物）被封装或附着到分子系统，运输到感兴趣的区域（例如肿瘤），并释放以作用于靶区域。提出了一个具体的分子递送计划，涉及设计和合成超分子主-客体表面活性剂，其可以形成胶束或囊泡，大细胞样分子结构，可以掺入药物分子，并且可以被触发以破坏以在靶位点释放药物。因此，该项目涉及基础和有针对性的应用研究的平衡组合。