Characterization of Solute Transport Processes in Fishes

鱼类溶质运输过程的表征

• 批准号: RGPIN-2022-03405
• 负责人: Goss, Gregory
• 金额: $ 2.84万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=744744
• 关键词: Characterization; Solute; Transport; Processes; Fishes

This research will investigate the functional evolution of ion, acid-base, and solute transporters and their unique roles in helping fish to cope with extreme environments. I will study a variety of acid-tolerant and acid-intolerant freshwater fish species will be undertaken to investigate the molecular mechanisms responsible for allowing certain freshwater fish to occupy waters with very low ion concentrations and low pH. In marine environments, the research will examine the unique adaptations in ion, acid-base, and solute transporters that enable the opportunistic rotting carcass scavenging Pacific hagfish possess to survive in a putrefying environment inside these carcasses. We will examine how the unique stress steroid profiles in hagfish may be linked to the unique strategy of ionoconforming in the plasma of  hagfish impact and shed light on how hagfish can controls their ion and acid base regulation. This research explores the fundamental nature of the evolution of solute transporter and will integrate these traits into the current evolutionary theories of vertebrate evolution. The results of this research will be of intense interest to evolutionary scientists, comparative physiologists, fisheries managers, and biomedical scientists.

这项研究将研究离子，酸碱和可溶性转运蛋白的功能演化及其在帮助鱼类应对极端环境中的独特作用。我将研究各种耐酸和酸耐耐酸的淡水鱼类，以研究负责允许某些淡水鱼占据非常低离子浓度和低pH的水的分子机制。在海洋环境中，该研究将检查离子，酸碱和可溶性转运蛋白的独特适应，以使机会腐烂的car体清除太平洋hag鱼在这些car体内的腐烂环境中拥有生存。我们将研究Hagfish中独特的应力类固醇特征如何与Hagfish撞击等离子体中的电离构成的独特策略有关，并阐明了Hagfish如何控制其离子和酸碱的调节。这项研究探讨了可溶性转运蛋白进化的基本性质，并将这些特征纳入当前脊椎动物进化的进化论。这项研究的结果将引起进化科学家，比较生理学家，渔业经理和生物医学科学家的强烈兴趣。