Characterization of Solute Transport Processes in Fishes

鱼类溶质运输过程的表征

• 批准号: RGPIN-2022-03405
• 负责人: Goss, Gregory
• 金额: $ 2.84万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=744744
• 关键词: Characterization; Solute; Transport; Processes; Fishes

This research will investigate the functional evolution of ion, acid-base, and solute transporters and their unique roles in helping fish to cope with extreme environments. I will study a variety of acid-tolerant and acid-intolerant freshwater fish species will be undertaken to investigate the molecular mechanisms responsible for allowing certain freshwater fish to occupy waters with very low ion concentrations and low pH. In marine environments, the research will examine the unique adaptations in ion, acid-base, and solute transporters that enable the opportunistic rotting carcass scavenging Pacific hagfish possess to survive in a putrefying environment inside these carcasses. We will examine how the unique stress steroid profiles in hagfish may be linked to the unique strategy of ionoconforming in the plasma of  hagfish impact and shed light on how hagfish can controls their ion and acid base regulation. This research explores the fundamental nature of the evolution of solute transporter and will integrate these traits into the current evolutionary theories of vertebrate evolution. The results of this research will be of intense interest to evolutionary scientists, comparative physiologists, fisheries managers, and biomedical scientists.

本研究将探讨离子，酸碱和溶质转运蛋白的功能演变及其在帮助鱼类科普极端环境中的独特作用。我会研究不同的耐酸性和不耐酸性淡水鱼品种，探讨某些淡水鱼在低离子浓度和低pH值的沃茨生存的分子机制。和溶质转运蛋白，使机会主义腐烂的尸体清除太平洋八目鳗拥有生存在腐烂的环境中，这些尸体内。我们将研究如何在盲鳗独特的应力类固醇配置文件可能与独特的策略ionocomforming在盲鳗的影响，并阐明如何盲鳗可以控制他们的离子和酸碱调节的血浆。本研究探索溶质转运蛋白进化的基本性质，并将这些特征整合到目前的脊椎动物进化理论中。这项研究的结果将引起进化科学家、比较生理学家、渔业管理者和生物医学科学家的浓厚兴趣。