Strengthening the use of XtalFluor reagents in organic synthesis and novel approaches to pentafluorosulfanyl-containing molecules

加强 XtalFluor 试剂在有机合成中的应用以及含五氟硫基分子的新方法

• 批准号: 515855-2017
• 负责人: Paquin, JeanFrançois
• 金额: $ 3.28万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=689111
• 关键词: Strengthening; use; XtalFluor; reagents; organic

The projects described herein aim at the development of new synthetic tools, either reactions or reagents, forthe preparation of organic compounds, in particular fluorine-containing molecules which are of high interest inpharmaceutical industry, in agrochemistry as well as in material sciences. Specific objectives are: 1) theimprovement of the deoxofluorination reaction using OmegaChem's XtalFluor reagents; 2) the discovery ofnew transformations using OmegaChem's XtalFluor reagents for the synthesis of fluorinated (trifluoromethylthioethers, trifluoromethyl ethers and monofluoroalkenes) and non-fluorinated compounds (aldehydes and1,1-diarylcyclopropanes); and 3) the development of novel synthetic approaches topentafluorosulfanyl-containing compounds. Overall, these projects are significant in the context thatOmegaChem is continually working to introduce on the market new molecules that can be integrated to thedesign of more complex structures demonstrating innovative properties and increased efficiency.

本文所述项目的目的是开发新的合成工具，无论是反应还是试剂，以制备有机化合物，特别是制药业、农业化学和材料科学高度关注的含氟分子。具体目标是：1)使用OmegaChem的XtalFluor试剂改进脱氧氟化反应；2)发现利用欧米伽化学的XtalFluor试剂合成含氟（三氟甲基硫醚、三氟甲基醚和单氟烯烃）和非含氟化合物（醛和1,1-二芳基环丙烷）的新转化；3)含五氟磺酰化合物合成新途径的发展。总的来说，这些项目在atomegachem不断努力向市场推出新分子的背景下具有重要意义，这些新分子可以集成到更复杂结构的设计中，展示创新特性和提高效率。