Strengthening the use of XtalFluor reagents in organic synthesis and novel approaches to pentafluorosulfanyl-containing molecules

加强 XtalFluor 试剂在有机合成中的应用以及含五氟硫基分子的新方法

• 批准号: 515855-2017
• 负责人: Paquin, JeanFrançois
• 金额: $ 3.28万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=696919
• 关键词: Strengthening; use; XtalFluor; reagents; organic

The projects described herein aim at the development of new synthetic tools, either reactions or reagents, for the preparation of organic compounds, in particular fluorine-containing molecules which are of high interest in pharmaceutical industry, in agrochemistry as well as in material sciences. Specific objectives are: 1) the improvement of the deoxofluorination reaction using OmegaChem's XtalFluor reagents; 2) the discovery of new transformations using OmegaChem's XtalFluor reagents for the synthesis of fluorinated (trifluoromethyl thioethers, trifluoromethyl ethers and monofluoroalkenes) and non-fluorinated compounds (aldehydes and 1,1-diarylcyclopropanes); and 3) the development of novel synthetic approaches to pentafluorosulfanyl-containing compounds. Overall, these projects are significant in the context that OmegaChem is continually working to introduce on the market new molecules that can be integrated to the design of more complex structures demonstrating innovative properties and increased efficiency.

本文描述的项目旨在开发新的合成工具，无论是反应还是试剂， 制备有机化合物，特别是在制备含氟分子方面具有高度兴趣的含氟分子， 制药工业，农业化学以及材料科学。具体目标是：（1） 使用OmegaChem的XtalFluor试剂改进脱氧核苷反应; 2）发现 使用OmegaChem的XtalFluor试剂合成氟化（三氟甲基） 硫醚、三氟甲基醚和单氟烯烃）和非氟化化合物（醛和 1，1-二芳基环丙烷）;和3）开发新的合成方法， 含五氟硫烷基的化合物。总的来说，这些项目意义重大， OmegaChem一直致力于在市场上推出新的分子，这些分子可以与 设计更复杂的结构，展示创新的性能和更高的效率。