Strengthening the use of XtalFluor reagents in organic synthesis and novel approaches to pentafluorosulfanyl-containing molecules

加强 XtalFluor 试剂在有机合成中的应用以及含五氟硫基分子的新方法

• 批准号: 515855-2017
• 负责人: Paquin, JeanFrançois
• 金额: $ 3.28万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=661513
• 关键词: Strengthening; use; XtalFluor; reagents; organic

The projects described herein aim at the development of new synthetic tools, either reactions or reagents, for**the preparation of organic compounds, in particular fluorine-containing molecules which are of high interest in**pharmaceutical industry, in agrochemistry as well as in material sciences. Specific objectives are: 1) the**improvement of the deoxofluorination reaction using OmegaChem's XtalFluor reagents; 2) the discovery of**new transformations using OmegaChem's XtalFluor reagents for the synthesis of fluorinated (trifluoromethyl**thioethers, trifluoromethyl ethers and monofluoroalkenes) and non-fluorinated compounds (aldehydes and**1,1-diarylcyclopropanes); and 3) the development of novel synthetic approaches to**pentafluorosulfanyl-containing compounds. Overall, these projects are significant in the context that**OmegaChem is continually working to introduce on the market new molecules that can be integrated to the**design of more complex structures demonstrating innovative properties and increased efficiency.

本文所述的项目旨在开发新的合成工具，无论是反应还是试剂，用于制备有机化合物，特别是在制药工业、农业化学以及材料科学中具有高度兴趣的含氟分子。具体目标是：1）** 使用OmegaChem的XtalFluor试剂改进脱氧反应; 2）发现 ** 使用OmegaChem的XtalFluor试剂合成氟化（三氟甲基 ** 硫醚、三氟甲基醚和单氟烯烃）和非氟化化合物（醛和 ** 1，1-二芳基环丙烷）的新转化; 3）开发合成 ** 含五氟硫烷基化合物的新方法。总的来说，这些项目在 **OmegaChem不断努力向市场推出新分子的背景下具有重要意义，这些新分子可以整合到更复杂结构的 ** 设计中，展示创新特性和更高的效率。