Alstoscholarisines类单萜吲哚生物碱是近来从云南西双版纳传统药用植物糖胶树中分离得到的一类结构新颖的天然产物。初步的药理研究表明，这类天然产物能显著提升成年神经干细胞的增殖能力。迄今为止，对该类天然产物的全合成研究还没有一例文献报道。我们试图利用吲哚C2位选择性的烯基化反应，不对称Michael加成反应，不对称Diels-Alder反应，retro-Aldol反应，六元醚环选择性环化反应，选择性还原环化反应，吲哚NH对亚胺的加成环化反应为关键反应，通过两条路线，展开Alstoscholarisine A，B，C，D，E五个天然产物的不对称全合成研究工作。并以此为契机，对该类化合物的结构与活性进行研究。

Alstoscholarisines, as a kind of the natural products possessing novel structure, were isolated from the leaves of Alstonia scholaris collected in Xishuangbanna of Yunnan Province. These natural products can promote adult neuronal stem cells (NSCs) proliferation significantly in preliminary biological assay. To date, there is no reported on the total synthesis of Alstoscholarisines. We propose two routes for asymmetric total synthesis of Alstoscholarisine A, B, C, D and E, using C-2 selective alkenylation of indoles, asymmetric Michael addition, asymmetric Diels-Alder reaction, retro-Aldol reaction, 6-member-ring etherification reaction, selective reduction, N-H addition to imine as key steps. Moreover, we plan studies on the relationship between the structures and biological activities.